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Animal models of inflammatory bowel disease

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Book cover In Vivo Models of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Concluding remarks

Experience in IBD animal modeling has shown us that an ideal animal model cannot be achieved, as the human disease is chronic, unrelenting with multiple remissions and relapses. Despite this shortcoming, the number of animal models of inflammation that relatively mimic IBD either naturally, spontaneously or phenotypically through experimental physical, immunological or genetic manipulations has significantly increased. Many of these models have helped us dissect and substantially advance our understandings of the pathogenesis of IBD, at the same time as providing an unprecedented opportunity for identifying targets for therapeutic intervention and prevention strategies. Since so many experimental animal models are now available, investigators must take into consideration the species, strains, substrains, the microenvironment in which they live and the mediators involved in each of these models, for application to preclinical testing to manipulate the immune system or to develop vaccines or gene therapy.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology and Office of Research, Drexel University College of Medicine, Philadelphia, USA

    Sreekant Murthy

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  1. Novartis Institutes for Biomedical Research Respiratory Disease Area, Novartis Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex, UK

    Christopher S. Stevenson

  2. Johnson and Johnson PRD, Welsh & McKean Rd, Spring House, PA, 19477, USA

    Lisa A. Marshall

  3. Portfolio, Program and Alliance Management BiogenIdec, 14 Cambridge Center, Cambridge, MA, 02142, USA

    Douglas W. Morgan

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Murthy, S. (2006). Animal models of inflammatory bowel disease. In: Stevenson, C.S., Marshall, L.A., Morgan, D.W. (eds) In Vivo Models of Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7760-1_6

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  • DOI: https://doi.org/10.1007/978-3-7643-7760-1_6

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