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Psoriasis and psoriatic arthritis: a clinical review

  • Allison J. Brown
  • Neil J. Korman
Part of the Milestones in Drug Therapy book series (MDT)

Abstract

Psoriasis is a common, systemic, inflammatory disease with genetic features that affects the skin and/or the joints and may be associated with significant morbidity. Psoriasis has a major impact on a patients’ quality of life, which may not correlate with disease severity as measured by the physician. In recent years, extensive research on psoriasis has demonstrated this disease to be an immunologically mediated disorder. The development of targeted immunotherapeutic agents to treat psoriasis and psoriatic arthritis has been a critical advance in the care of patients with these conditions. This chapter will focus on the clinical features of psoriasis and psoriatic arthritis, as well as potential triggers and systemic associations. The ability to identify psoriasis and knowledge of the disease associations and triggers will aid in the physician’s capacity to most effectively treat patients with this disease.

Keywords

Psoriatic Arthritis Psoriasis Patient Psoriatic Patient Nail Plate Pustular Psoriasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Griffiths CEM, Christophers E, Barker JNWN, Chalmers RJG, Chimenti S, Krueger GG, Leonarid C, Menter A, Ortonne JP, Fry L (2007) A classification of psoriasis vulgaris according to phenotype. Br J Dermatol 156: 258–262PubMedCrossRefGoogle Scholar
  2. 2.
    Biondi OC, Scarpa R, Pucino A, Oriente P (1989) Psoriasis and psoriatic arthritis. Dermatological and rheumatological co-operative clinical report. Acta Dermatol Venereol 146(suppl): 69–71Google Scholar
  3. 3.
    McMillin BD, Maddern BR, Graham WR (1999) A role for tonsillectomy in the treatment of psoriasis? Ear, Nose and Throat J 78: 155–158Google Scholar
  4. 4.
    Boyd AS, Menter A (1989) Erythrodermic psoriasis: precipitating factors, course, and prognosis in 50 patients. J Am Acad Dermatol 21: 985–991PubMedGoogle Scholar
  5. 5.
    Farber EM, Nall ML (1974) The natural history of psoriasis in 5600 patients. Dermatologica 148: 1–18PubMedGoogle Scholar
  6. 6.
    Lewin K, De Wit S, Ferrington RA (1971) Nail involvement in psoriasis: a clinicopathological study. In: EM Farber, AJ Cox (eds): Proceedings of the International Symposium on Psoriasis, Stanford University Press, California, 111–123Google Scholar
  7. 7.
    Farber EM, Nall L (1992) Nail Psoriasis. Cutis 50: 174–178PubMedGoogle Scholar
  8. 8.
    Scher RK (1985) Psoriasis of the nail. Dermatol Clinics 3: 387–394Google Scholar
  9. 9.
    Hietanen J, Salo OP, Kanerva L, Juvakoski T (1984) Study of the oral mucosa in 200 consecutive patients. Scand J Dent Res 92: 50–54PubMedGoogle Scholar
  10. 10.
    Morris LF, Phillips CM, Binnie WH, Sander HM, Silverman AK, Menter MA (1992) Oral lesions in patients with psoriasis: a controlled study. Cutis 49: 339–344PubMedGoogle Scholar
  11. 11.
    Zhu JF, Kaminski MJ, Pulitzer DR, Hu J, Thomas HF (1996) Psoriasis: pathophysiology and oral manifestations. Oral Dis 2: 135–144PubMedGoogle Scholar
  12. 12.
    Yosipovitch G, Goon A, Wee J, Chan YH, Goh CL (2000) The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis. Br J Dermatol 143: 969–973PubMedCrossRefGoogle Scholar
  13. 13.
    Koo J (1996) Population-based epidemiologic study of psoriasis with emphasis on quality of life assessment. Dermatol Clin 14: 485–496PubMedCrossRefGoogle Scholar
  14. 14.
    Szepietowski JC, Reich A, Wisnicka B (2004) Pruritus and psoriasis (letter). Brit J Dermatol 151: 1284CrossRefGoogle Scholar
  15. 15.
    Krueger GG, Eyre RW (1984) Trigger factors in psoriasis. In: G Weinstein, MJ Voorhees (eds): Dermatol Clin. Philadelphia, Saunders, p. 373Google Scholar
  16. 16.
    Melski JW, Bernhard JD, Stern RS (1983) The Koebner (isomorphic) response in psoriasis: associations with early age of onset and multiple previous therapies. Arch Dermatol 19: 655–659CrossRefGoogle Scholar
  17. 17.
    Nyfors A, Lemholt K (1975) Psoriasis in children: a short review and a survey of 245 cases. Br J Dermatol 92: 437–442PubMedCrossRefGoogle Scholar
  18. 18.
    Whyte HJ, Baughman RD (1964) Acute guttate psoriasis and streptococcal infection. Arch Dermatol 89: 350–356PubMedGoogle Scholar
  19. 19.
    Telfer NR, Chalmers RJG, Whale K, Colman G (1992) The role of streptococcal infection in the initiation of guttate psoriasis. Arch Dermatol 128: 39–42PubMedCrossRefGoogle Scholar
  20. 20.
    Wilson JK, Al-Suwaidan SN, Krowchuk D, Feldman SR (2003) Treatment of psoriasis in children: is there a role for antibiotic therapy and tonsillectomy? Ped Dermatol 20: 11–15CrossRefGoogle Scholar
  21. 21.
    Duvic M (1991) Papulosquamous disorders associated with human immunodeficiency virus infection. Dermatol Clin 9: 523–530PubMedCrossRefGoogle Scholar
  22. 22.
    Mallon E, Bunker CB (2000) HIV-associated psoriasis. AIDS Patient Care STDs 14: 239–246PubMedCrossRefGoogle Scholar
  23. 23.
    Colebunders R, Blot K, Meriens V, Dock P (1992) Psoriasis regression in terminal AIDS. Lancet 339: 1110PubMedCrossRefGoogle Scholar
  24. 24.
    Johnson TM, Duvic M, Rapini RP, Rios A (1985) AIDS exacerbates psoriasis (letter). N Engl J Med 313: 1415PubMedGoogle Scholar
  25. 25.
    Fortune DG, Richards HL, Main CJ, Griffiths CE (1998) What patients with psoriasis believe about their condition. J Am Acad Dermatol 39: 196–201PubMedCrossRefGoogle Scholar
  26. 26.
    Fortune DG, Richards HL, Kirby B, McElhone K, Markham T, Rogers S, Main CJ, Griffiths CE (2003) Psychological distress impairs clearance of psoriasis in patients treated with photochemotherapy. Arch Dermatol 139: 752–756PubMedCrossRefGoogle Scholar
  27. 27.
    Fortune DG, Richards HL, Kirby B, Bowcock S, Main CJ, Griffiths CEM (2002) A cognitivebehavioural symptom management program as an adjunct in psoriasis therapy. Br J Dermatol 146: 458–465PubMedCrossRefGoogle Scholar
  28. 28.
    Fortune DG, Richards HL, Griffiths CEM, Main CJ (2004) Targeting cognitive-behaviour therapy to patients’ implicit model of psoriasis: results from a patient preference controlled trial. Br J Clin Psychol 43: 65–82PubMedCrossRefGoogle Scholar
  29. 29.
    Tsankov N, Angelova I, Kazandjieva J (2000) Drug-induced psoriasis: recognition and management. Am J Clin Dermatol 1: 159–165PubMedCrossRefGoogle Scholar
  30. 30.
    Higgins E (2000) Alcohol, smoking, and psoriasis. Clin Exp Dermatol 25: 107–110PubMedCrossRefGoogle Scholar
  31. 31.
    Poikolainen K, Reunala T, Kiarvonen J, Lauharanta J, Karkkainen P (1990) Alcohol intake: a risk factor for psoriasis in young and middle aged men? Br Med J 300: 780–783CrossRefGoogle Scholar
  32. 32.
    Poikolainen K, Reunala T, Karvonen J (1994) Smoking, alcohol and life events related to psoriasis among women. Br J Dermatol 130: 473–477PubMedCrossRefGoogle Scholar
  33. 33.
    Duffy DL, Spelman LA, Martin NG (1993) Psoriasis in Australian twins. J Am Acad Dermatol 29: 428–434PubMedGoogle Scholar
  34. 34.
    Poikolainen K, Karvonen J, Pukkala E (1999) Excess mortality related to alcohol and smoking among hospital-treated patients with psoriasis. Arch Dermatol 135: 1490–1493PubMedCrossRefGoogle Scholar
  35. 35.
    Herron MD, Hinckley M, Hoffman MS, Papenfuss J, Hansen CB, Callis KP, Krueger GG (2005) Impact of obesity and smoking on psoriasis presentation and management. Arch Dermatol 141: 1527–1534PubMedCrossRefGoogle Scholar
  36. 36.
    Naldi L, Chatenoud L, Linder D, Belloni FA, Peserico A, Virgili AR, Bruni PL, Ingordo V, Lo Scocco G, Solaroli C et al. (2005) Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case-control study. J Invest Dermatol 125: 61–67PubMedCrossRefGoogle Scholar
  37. 37.
    Fortes C, Mastroeni S, Leffondre K, Sampogna F, Melchi F, Mazzotti E, Pasquini P, Abeni D (2005) Relationship between smoking and the clinical severity of psoriasis. Arch Dermatol 141: 1580–1584PubMedCrossRefGoogle Scholar
  38. 38.
    Mowad CM, Margolis DJ, Halpern AC, Suri B, Synnestvedt M, Guzzo CA (1998) Hormonal influences on women with psoriasis. Cutis 61: 257–260PubMedGoogle Scholar
  39. 39.
    Murase JE, Chan KK, Garite TJ, Cooper DM, Weinstein GD (2005) Hormonal effect on psoriasis in pregnancy and post partum. Arch Dermatol 141: 601–606PubMedCrossRefGoogle Scholar
  40. 40.
    Boyd AS, Morris LF, Phillips CM, Menter MA (1996) Psoriasis and pregnancy: hormone and immune system interaction. Int J Dermatol 35: 169–172PubMedCrossRefGoogle Scholar
  41. 41.
    Christensen TE, Callis KP, Papenfuss J, Hoffman MS, Hansen CB, Wong B, Panko JM, Krueger GG (2006) Observations of psoriasis in the absence of therapeutic intervention identifies two unappreciated morphologic variants, thin-plaque and thick-plaque psoriasis, and their associated phenotypes. J Invest Dermatol 126: 2397–2403PubMedCrossRefGoogle Scholar
  42. 42.
    Johnson MT, Roberts J (1978) Skin conditions and related need for medical care among persons 1–74 years. Vital Health Stat 11: 1–72Google Scholar
  43. 43.
    Naldi L (2004) Epidemiology of psoriasis. Curr Drug Targets Inflamm Allergy 3: 121–128PubMedCrossRefGoogle Scholar
  44. 44.
    Lebwohl M (2003) Psoriasis. Lancet 361: 1197–1204PubMedCrossRefGoogle Scholar
  45. 45.
    Kenney JA (1965) Management of dermatoses peculiar to Negroes. Arch Dermatol 91: 126–129PubMedGoogle Scholar
  46. 46.
    Gelfand JM, Stern RS, Nijsten T, Feldman SR, Thomas J, Kist J, Rolstad T, Margolis DJ (2005) The prevalence of psoriasis in African Americans: results from a population-based study. J Am Acad Dermatol 52: 23–26PubMedCrossRefGoogle Scholar
  47. 47.
    Lomholt G (1971) Psoriasis in Uganda: A comparative study with other parts of Africa. In: EM Farber, AJ Cox (eds): Proceedings of the International Symposium on Psoriasis. Stanford University Press, California, 41–48Google Scholar
  48. 48.
    Schon MP, Boehncke WH (2005) Medical progress: Psoriasis. N Engl J Med 352: 1899–1912PubMedCrossRefGoogle Scholar
  49. 49.
    Buntin D, Skinner R, Rosenberg E (1983) Onset of psoriasis at age 108. J Am Acad Dermatol 9: 276–277PubMedCrossRefGoogle Scholar
  50. 50.
    Holgate MC (1975) The age-of-onset of psoriasis and the relationship to parental psoriasis. Br J Dermatol 92: 443–448PubMedCrossRefGoogle Scholar
  51. 51.
    Ferrandiz C, Pujol RM, Garcia-Patos V, Bordas X, Smandia JA (2002) Psoriasis of early and late onset: a clinical and epidemiologic study from Spain. J Am Acad Dermatol 46: 867–873PubMedCrossRefGoogle Scholar
  52. 52.
    Farber EM, Nall ML (1971) Genetics of psoriasis: Twin study. In: EM Farber, AJ Cox (eds): Proceedings of the International Symposium on Psoriasis. Stanford University Press, California, 7–13Google Scholar
  53. 53.
    Henseler T, Christophers E (1985) Psoriasis of early and late onset: characterizations of two types of psoriasis vulgaris. J Am Acad Dermatol 13: 450–456PubMedGoogle Scholar
  54. 54.
    Yates VM, Watkinson G, Kelman A (1982) Further evidence for an association between psoriasis, Crohn’s disease and ulcerative colitis. Br J Dermatol 106: 323–330PubMedCrossRefGoogle Scholar
  55. 55.
    Najarian DJ, Gottlieb AB (2003) Connections between psoriasis and Crohn’s disease. J Am Acad Dermatol 48: 805–821PubMedCrossRefGoogle Scholar
  56. 56.
    Mallbris L, Granath F, Hamsten A, Stahle M (2006) Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol 54: 614–621PubMedCrossRefGoogle Scholar
  57. 57.
    Naldi L, Parazzini F, Peli L, Chatenoud L, Cainelli T (1996) Dietary factors and the risk of psoriasis. Results of an Italian case-control study. Br J Dermatol 134: 101–106PubMedCrossRefGoogle Scholar
  58. 58.
    Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM (2006) Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol 55: 829–835PubMedCrossRefGoogle Scholar
  59. 59.
    Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB (2006) Risk of myocardial infarction in patients with psoriasis. J Am Med Assoc 296: 1735–1741CrossRefGoogle Scholar
  60. 60.
    Shapiro J, Cohen AD, David M, Hodak E, Chodik G, Viner A, Kremer E, Heymann A (2007) The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: A case-control study. J Am Acad Dermatol 56: 629–634PubMedCrossRefGoogle Scholar
  61. 61.
    Sommer DM, Jenisch S, Suchan M, Christophers E, Weichenthal M (2006) Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res 298: 321–328PubMedCrossRefGoogle Scholar
  62. 62.
    Zachariae N, Sogaard H (1973) Liver biopsy in psoriasis. A controlled study. Dermatologica 146: 149–155PubMedCrossRefGoogle Scholar
  63. 63.
    Christophers E (2001) Psoriasis-epidemiology and clinical spectrum. Clin Exp Dermatol 26: 314–320PubMedCrossRefGoogle Scholar
  64. 64.
    Gelfand JM, Berlin J, Van Voorhees A, Margolis DJ (2003) Lymphoma rates are low but increased in patients with psoriasis: results from a population-based cohort study in the United Kingdom. Arch Dermatol 139: 1425–1429PubMedCrossRefGoogle Scholar
  65. 65.
    Gelfand JM, Shin DB, Neimann AL, Xingmei Wang, Margolis DJ, Troxel AB (2006) The risk of lymphoma in patients with psoriasis. J Invest Dermatol 126: 2194–2201PubMedCrossRefGoogle Scholar
  66. 66.
    Moll JM, Wright V (1973) Psoriatic Arthritis. Semin Arthritis Rheum 3: 55–78PubMedCrossRefGoogle Scholar
  67. 67.
    Gladman DD, Atoni C, Mease P, Clegg DO, Nash P (2005) Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis 64(suppl II): ii14–ii17PubMedCrossRefGoogle Scholar
  68. 68.
    Gladman DD (2002) Current concepts in psoriatic arthritis. Curr Opin Rheumatol 14: 361–366PubMedCrossRefGoogle Scholar
  69. 69.
    Gladman DD (1995) Psoriatic arthritis. Baillieres Clin Rheumatol 9: 319–329PubMedCrossRefGoogle Scholar
  70. 70.
    Boumpas DT, Tassiulas IO (1997) Psoriatic arthritis. In: JH Klippel (ed.): Primer of the Rheumatic Diseases. Arthritis Foundation, Atlanta, 175–179Google Scholar
  71. 71.
    Gladman DD, Shuckett R, Russell ML, Thorne JC, Schachter RK (1987) Psoriatic arthritis (PSA)-An analysis of 220 patients. Quart J Med 62: 127–141PubMedGoogle Scholar
  72. 72.
    Moul DK, Korman NJ (2005) The early signs and symptoms of psoriatic arthritis: the importance of early evaluation and treatment. Psoriasis Forum 11: 4–6Google Scholar
  73. 73.
    Goupille P, Laulan J, Vedere V, Kaplan G, Valat JP (1995) Psoriatic onycho-periostitis. Report of three cases. Scand J Rheumatol 24: 53–54PubMedCrossRefGoogle Scholar
  74. 74.
    Siannis F, Farewell V, Cook R, Schentag C, Gladman D (2006) Clinical and radiological damage in psoriatic arthritis. Ann Rheum Dis 65: 478–481PubMedCrossRefGoogle Scholar
  75. 75.
    Johnson SR, Schentag CT, Gladman DD (2005) Autoantibodies in biological agent naïve patients with psoriatic arthritis. Ann Rheum Dis 64: 770–772PubMedCrossRefGoogle Scholar
  76. 76.
    Cruyssen VB, Hoffman IE, Zmierczak H, Van den Berghe M, Kruithof E, De Rycke L, Mielants H, Veys EM, Baeten D, De Keyser F (2005) Anti-citrullinated peptide antibodies may occur in patients with psoriatic arthritis. Ann Rheum Dis 64:1145–1149CrossRefGoogle Scholar
  77. 77.
    Bogliolo L, Alpini C, Caporali R, Scire CA, Moratti R, Montecucco C (2005) Antibodies to cyclic citrullinated peptides in psoriatic arthritis. J Rheumatol 32: 511–515PubMedGoogle Scholar
  78. 78.
    Gladman DD (1998) Clinical aspects of the spondyloarthropathies. Am J Med Sci 316: 234–238PubMedCrossRefGoogle Scholar
  79. 79.
    Gladman DD, Anhorn KA, Schachter RK, Mervart H (1986) HLA antigens in psoriatic arthritis. J Rheumatol 13: 586–592PubMedGoogle Scholar
  80. 80.
    Gladman DD (1994) The natural history of psoriatic arthritis. In: V Wright, PS Helliwel (eds): Bailliere’s Clinical Rheumatology. International Practice and Research. Bailliere Tindall, London, 379–394Google Scholar
  81. 81.
    Kane D, Stafford L, Bresnihan B, FitzGerald O (2003) A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience. Rheumatology 42: 1460–1468PubMedCrossRefGoogle Scholar
  82. 82.
    Buskila D, Langevitz P, Gladman DD, Urowitz S, Smythe HA (1992) Patients with rheumatoid arthritis are more tender than those with psoriatic arthritis. J Rheumatol 19: 1115–1119PubMedGoogle Scholar
  83. 83.
    Cantini F, Salvarani C, Olivieri I, Macchioni L, Miccoli L, Padula A, Falcone C, Boiardi L, Bozza A, Barozzi L et al. (2001) Distal extremity swelling with pitting edema in psoriatic arthritis: a case-control study. Clin Exp Rheumatol 19: 291–296PubMedGoogle Scholar
  84. 84.
    Jones SM, Armas JB, Cohen MG, Lovell CR, Evison G, McHugh NJ (1994) Psoriatic arthritis: outcome of disease subsets and relationship of joint disease to nail and skin disease. Br J Rheumatol 33: 834–839PubMedCrossRefGoogle Scholar
  85. 85.
    Shbeeb M, Uramoto KM, Gibson LE, O’Fallon WM, Gabriel SE (2000) The epidemiology of psoriatic arthritis in Olmsted County, Minnesota, USA, 1982–1991. J Rheumatol 27: 1247–1250PubMedGoogle Scholar
  86. 86.
    Gelfand JM, Gladman DD, Mease PJ, Smith N, Margolis DJ, Nijsten T, Stern RS, Feldman SR, Rolstad T (2005) Epidemiology of psoriatic arthritis in the population of the United States. J Am Acad Dermatol 53: 573–577PubMedCrossRefGoogle Scholar
  87. 87.
    Brockbank J, Gladman D (2002) Diagnosis and management of psoriatic arthritis. Drugs 62: 2447–2460PubMedCrossRefGoogle Scholar
  88. 88.
    Madland TM, Apalset EM, Johannessen AE, Rossebo B, Brun JG (2005) Prevalence, disease manifestations, and treatment of psoriatic arthritis in Western Norway. J Rheumatol 32: 1918–1922PubMedGoogle Scholar
  89. 89.
    Williamson L, Dalbeth N, Dockerty JL, Gee BC, Weatherall R, Wordsworth BP (2004) Extended report: nail disease in psoriatic arthritis — clinically important, potentially treatable and often overlooked. Rheumatology 43: 790–794PubMedCrossRefGoogle Scholar
  90. 90.
    Lavaroni G, Kokelj F, Pauluzzi P, Trevisan G (1994) The nails in psoriatic arthritis. Acta Derm Venereol 186(suppl): 113Google Scholar
  91. 91.
    Oriente P, Biondi-Oriente C, Scarpa R (1994) Psoriatic arthritis: clinical manifestations. Bailleres Clin Rheumatol 8: 277–294CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag/Switzerland 2008

Authors and Affiliations

  • Allison J. Brown
    • 1
  • Neil J. Korman
    • 1
  1. 1.Department of Dermatology, Murdough Family Center for PsoriasisUniversity Hospitals Case Medical CenterClevelandUSA

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