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The fibroblast and myofibroblast in inflammatory angiogenesis

  • Patrick Auguste
  • François Vincent
  • Giulio Gabbiani
  • Alexis Desmoulière
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Normal wound healing includes a number of overlapping phases. After injury, there is an early inflammatory step characterised by haemorrhage and clotting. At this time, the wound has a provisional serum-derived extracellular matrix, which serves to seal the wound temporarily and allows the invasion of cells that carry out the repair process. In the next phase, consisting of granulation tissue development, fibroblasts invade the wound and commence replacing the provisional matrix with a more mature wound matrix. The fibroblasts present during the early granulation tissue phase resemble immature fibroblasts with a highly synthetic appearance. However, as the granulation tissue phase proceeds, fibroblasts start showing a new phenotype with prominent contractile structures represented by microfilament bundles or stress fibres; these structures express contractile proteins typical of smooth muscle cells, particularly of vascular smooth muscle cells, such as α-smooth muscle actin [1]. Recently, it has been shown that α-smooth muscle actin is largely responsible for force production by the myofibroblast both in vitro and in vivo. Myofibroblast differentiation is a complex process, regulated, by at least one cytokine [transforming growth factor (TGF)-β1] [2], an extracellular matrix component (fibronectin ED-A) [3] as well as the presence of mechanical tension [4] (for review, see [5]). Lastly, in the resolution phase of healing, there is considerable loss of cellularity essentially through apoptosis of several cell types including myofibroblasts [6].

Keywords

Tumour Smooth Muscle Angiotensin Type Receptor Reaction Smooth MUSC Granulation Tissue Development Migration Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Patrick Auguste
    • 1
    • 2
  • François Vincent
    • 3
  • Giulio Gabbiani
    • 4
  • Alexis Desmoulière
    • 5
  1. 1.INSERM, U889BordeauxFrance
  2. 2.University Victor Segalen Bordeaux 2BordeauxFrance
  3. 3.Centre Hospitalier UniversitaireLimogesFrance
  4. 4.Department of Pathology and ImmunologyCentre Médical UniversitaireGenevaSwitzerland
  5. 5.Faculty of Pharmacy, Department of PhysiologyUniversity of LimogesLimogesFrance

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