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Applications of transcriptional profiling in antibiotics discovery and development

  • Hans Peter Fischer
  • Christoph Freiberg
Part of the Progress in Drug Research book series (PDR, volume 64)

Abstract

This chapter will review specific applications of microarray technology and related data analysis strategies in antibacterial research and development. We present examples of microarray applications spanning the entire antibiotics research and development pipeline, from target discovery, assay development, pharmacological evaluation, to compound safety studies. This review emphasizes the utility of microarrays for a systematic evaluation of novel chemistry as antibiotic agents. Transcriptional profiling has revolutionized the process of target elucidation and has the potential to offer substantial guidance in the identification of new targets. Microarrays will continue to be a workhorse of anti-infectives discovery programs ranging from efficacy assessments of antibiotics (‘forward pharmacology’) to drug safety evaluations (‘toxicogenomics’).

Keywords

Lyme Disease Antimicrob Agent Essential Gene Fatty Acid Biosynthesis Reporter Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 2007

Authors and Affiliations

  • Hans Peter Fischer
    • 1
  • Christoph Freiberg
    • 2
  1. 1.Genedata AGBaselSwitzerland
  2. 2.Pharma Research & DevelopmentBayer HealthCare AGGermany

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