Poxviruses pp 113-125 | Cite as

Genus Yatapoxvirus

  • Geoffrey L. Smith
Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)


Yatapoxviruses are a small group of Chordopoxviruses that infect humans and primates. There are two viruses in this genus, Ya ba monkey tumour virus (YMTV) and Ta napox virus (TANV), hence the name Yatapox. A third virus called Yaba-like disease virus (YLDV) is very closely related to TANV so that YLDV and TANV are considered strains of the same species. TANV and YMTV infect primates in equatorial Africa and these infections may be transmitted to man by biting insects as zoonoses. Notable feature of yatapoxviruses are their slow growth in cell culture and the ability of YMTV to induce tumours (histiocytomas) in primates. Here the properties of the Yatapoxvirus genus are described.


Rhesus Monkey West Nile Virus African Green Monkey Insect Bite Monkey Kidney Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Bearcroft WG, Jamieson MF (1958) An outbreak of subcutaneous tumors in rhesus monkeys. Nature 182: 195–196PubMedCrossRefGoogle Scholar
  2. 2.
    Andrewes CH, Allison AC, Armstrong JA, Bearcroft WG, Niven JSF, Pereira HG (1959) A virus disease of monkeys causing large superficial growths. Acta Unio internat contra cancrum 15Google Scholar
  3. 3.
    Niven JSF, Armstrong JA, Andrewes CH, Pereira HG, Valentine RC (1961) Subcutaneous growths in monkeys produced by a poxvirus. J Pathol Bacteriol 81: 1–14PubMedCrossRefGoogle Scholar
  4. 4.
    Feltz ET (1961) Proc Amer Assoc Cancer Res3Google Scholar
  5. 5.
    Sproul EE, Metzgar RS, Grace JT Jr (1963) The pathogenesis of Yaba virusinduced histiocytomas in primates. Cancer Res 23: 671–675PubMedGoogle Scholar
  6. 6.
    Kato S, Tsuru K, Miyamoto H (1965) Autoradiographic studies on the Yaba monkey tumor virus and host cell interaction. Biken J 8: 45–53PubMedGoogle Scholar
  7. 7.
    Owens G, Metzgar R, Grace JT, Jr. (1964) Ultrastructure and Related Immunologic Characteristics of the Yaba Virus. J Surg Res 26: 297–305CrossRefGoogle Scholar
  8. 8.
    De Harven E, Yohn DS (1966) The fine structure of the Yaba monkey tumor poxvirus. Cancer Res 26: 995–1008PubMedGoogle Scholar
  9. 9.
    Ambrus CM, Feltz ET, Grace JT Jr, Owens G (1963) A virus induced tumor in primates. Natl Cancer Inst Monogr 10: 447–458Google Scholar
  10. 10.
    Behbehani AM, Bolano CR, Kamitsuka PS, Wenner HA (1968) Yaba tumor virus. I. Studies on pathogenesis and immunity. Proc Soc Exp Biol Med 129: 556–561Google Scholar
  11. 11.
    Grace JT Jr, Mirand EA, Millian SJ, Metzgar RS (1962) Experimental studies of human tumors. Fed Proc 21: 32–36PubMedGoogle Scholar
  12. 12.
    Grace JT, Jr., Mirand EA (1963) Human susceptibility to a human tumor virus. Ann NY Acad Sci 108: 1123PubMedCrossRefGoogle Scholar
  13. 13.
    Grace JT Jr, Mirand EA (1965) Yaba virus infection in humans. Exp Med Surg 23: 213–216PubMedGoogle Scholar
  14. 14.
    Espana C (1971) Review of some outbreaks of viral disease in captive nonhuman primates. Lab Anim Sci 21: 1023–1031PubMedGoogle Scholar
  15. 15.
    Casey HW, Woodruff JM, Butcher WI (1967) Electron microscopy of a benign epidermal pox disease of rhesus monkeys. Am J Pathol 51: 431–446PubMedGoogle Scholar
  16. 16.
    Crandell RA, Casey HW, Brumlow WB (1969) Studies of a newly recognized poxvirus of monkeys. J Infect Dis 119: 80–88PubMedGoogle Scholar
  17. 17.
    Hall AS, McNulty WP (1967) A contagious pox disease in monkeys. J Am Vet Med Assoc 151: 833–838PubMedGoogle Scholar
  18. 18.
    Nicholas AH, McNulty WP (1968) In vitro characteristics of a poxvirus isolated from rhesus monkeys. Nature 217: 745–746PubMedCrossRefGoogle Scholar
  19. 19.
    Hull RN (1968) The simian viruses. In S Gard, C Hallauer, KF Meyer (eds): Virology Monographs. Springer-Verlag, Vienna, Volume 2, Die Virusforschung in Einzeldarstellungen, pp. 1–66Google Scholar
  20. 20.
    Downie AW, Taylor-Robinson CH, Caunt AE, Nelson GS, Manson-Bahr PE, Matthews TC (1971) Tanapox: a new disease caused by a poxvirus. Br Med J 1: 363–368PubMedGoogle Scholar
  21. 21.
    Downie AW, Espana C (1972) Comparison of Tanapox virus and Yaba-like viruses causing epidemic disease in monkeys. J Hyg (Lond) 70: 23–32Google Scholar
  22. 22.
    Knight JC, Novembre FJ, Brown DR, Goldsmith CS, Esposito JJ (1989) Studies on Tanapox virus. Virology 172: 116–124PubMedCrossRefGoogle Scholar
  23. 23.
    Lee HJ, Essani K, Smith GL (2001) The genome sequence of Yaba-like disease virus, a yatapoxvirus. Virology 281: 170–192PubMedCrossRefGoogle Scholar
  24. 24.
    Ambrus JL, Strandstrom HV (1966) Susceptibility of Old World monkeys to Yaba virus. Nature 211: 876PubMedCrossRefGoogle Scholar
  25. 25.
    Tsuchiya Y, Tagaya I (1971) Sero-epidemiological survey on Yaba and 1211 virus infections among several species of monkeys. J Hyg (Lond) 69: 445–451Google Scholar
  26. 26.
    Manson-Bahr PE, Downie AW (1973) Persistence of tanapox in Tana River valley. Br Med J 2: 151–153PubMedCrossRefGoogle Scholar
  27. 27.
    Axford JS, Downie AW (1979) Tanapox. A serological survey of the lower Tana River Valley. J Hyg (Lond) 83: 273–276Google Scholar
  28. 28.
    Jezek Z, Arita I, Szczeniowski M, Paluku KM, Ruti K, Nakano JH (1985) Human tanapox in Zaire: clinical and epidemiological observations on cases confirmed by laboratory studies. Bull World Health Organ 63: 1027–1035PubMedGoogle Scholar
  29. 29.
    Croitoru AG, Birge MB, Rudikoff D, Tan MH, Phelps RG (2002) Tanapox virus infection. Skinmed 1: 156–157PubMedGoogle Scholar
  30. 30.
    Dhar AD, Werchniak AE, Li Y, Brennick JB, Goldsmith CS, Kline R, Damon I, Klaus SN (2004) Tanapox infection in a college student. N Engl J Med 350: 361–366PubMedCrossRefGoogle Scholar
  31. 31.
    Stich A, Meyer H, Kohler B, Fleischer K (2002) Tanapox: first report in a European traveller and identification by PCR. Trans R Soc Trop Med Hyg 96: 178–179PubMedCrossRefGoogle Scholar
  32. 32.
    Zimmermann P, Thordsen I, Frangoulidis D, Meyer H (2005) Real-time PCR assay for the detection of tanapox virus and yaba-like disease virus. J Virol Methods 130: 149–153PubMedCrossRefGoogle Scholar
  33. 33.
    Downie AW, Espana C (1973) A comparative study of Tanapox and Yaba viruses. J Gen Virol 19: 37–49PubMedGoogle Scholar
  34. 34.
    Rouhandeh H, Vafai A, Kilpatrick D (1984) The morphogenesis of Yaba monkey tumor virus in a cynomolgus monkey kidney cell line. J Ultrastruct Res 86: 100–105PubMedCrossRefGoogle Scholar
  35. 35.
    Nagington J, Newton AA, Horne RW (1964) The structure of Orf virus. Virology 23: 461–472PubMedCrossRefGoogle Scholar
  36. 36.
    Law M, Hollinshead M, Lee HJ, Smith GL (2004) Yaba-like disease virus protein Y144R, a member of the complement control protein family, is present on enveloped virions that are associated with virus-induced actin tails. J Gen Virol 85: 1279–1290PubMedCrossRefGoogle Scholar
  37. 37.
    Kilpatrick D, Rouhandeh H (1987) The analysis of Yaba monkey tumor virus DNA. Virus Res 7: 151–157PubMedCrossRefGoogle Scholar
  38. 38.
    Kilpatrick DR, Rouhandeh H (1985) Cloning and physical mapping of Yaba monkey tumor virus DNA. Virology 143: 399–406PubMedCrossRefGoogle Scholar
  39. 39.
    Brunetti CR, Amano H, Ueda Y, Qin J, Miyamura T, Suzuki T, Li X, Barrett JW, McFadden G (2003) Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus. J Virol 77: 13335–13347PubMedCrossRefGoogle Scholar
  40. 40.
    Gubser C, Hue S, Kellam P, Smith GL (2004) Poxvirus genomes: a phylogenetic analysis. J Gen Virol 85: 105–117PubMedCrossRefGoogle Scholar
  41. 41.
    Feltz ET (1964) In vitro culture of Yaba virus-induced tumour from monkeys. Nature 202: 625–626PubMedCrossRefGoogle Scholar
  42. 42.
    Yohn DS, Grace JT Jr, Haendiges VA (1964) A quantitative cell culture assay for Yaba tumour virus. Nature 202: 881–883PubMedCrossRefGoogle Scholar
  43. 43.
    Tsuchiya Y, Tagaya I, Tsuruhara T (1969) Titration and extensive serial passages of Yaba virus in vitro. Jpn J Microbiol 13: 103–117PubMedGoogle Scholar
  44. 44.
    Olsen RG, Yohn DS (1970) Immunodiffusion analysis of Yaba poxvirus structural and associated antigens. J Virol 5: 212–220PubMedGoogle Scholar
  45. 45.
    Mediratta S, Essani K (1999) The replication cycle of tanapox virus in owl monkey kidney cells. Can J Microbiol 45: 92–96PubMedCrossRefGoogle Scholar
  46. 46.
    Rouhandeh H, Richards JC (1980) Surface membrane redistribution and stabilization of concanavalin A-specific receptors following Yaba tumor poxvirus infection. Biochim Biophys Acta 600: 301–312PubMedCrossRefGoogle Scholar
  47. 47.
    Rouhandeh H, Kilpatrick D, Vafai A (1982) The molecular biology of Yaba tumour pox virus: analysis of lipids, proteins and DNA. J Gen Virol 62: 207–218PubMedGoogle Scholar
  48. 48.
    Rouhandeh H, Vafai A (1982) A novel cell transformation with DNA-containing cytoplasmic Yaba tumor poxvirus. Virology 120: 77–92PubMedCrossRefGoogle Scholar
  49. 49.
    Schwartz J, Dales S (1971) Biogenesis of poxviruses: identification of four enzyme activities within purified Yaba tumor virus. Virology 45: 797–801PubMedCrossRefGoogle Scholar
  50. 50.
    Tsuchiya Y, Tagaya I (1979) Plaque formation by a host range mutant of vaccinia virus in non-permissive cells co-infected with Yaba virus. J Gen Virol 43: 193–202PubMedGoogle Scholar
  51. 51.
    Amano H, Ueda Y, Miyamura T (1995) Identification and characterization of the thymidine kinase gene of Yaba virus. J Gen Virol 76: 1109–1115PubMedCrossRefGoogle Scholar
  52. 52.
    Rouhandeh H, Rouhandeh ML (1973) Nucleic acid synthesis in cytoplasm of Yaba monkey tumor virus-infected cells. J Virol 12: 1407–1413PubMedGoogle Scholar
  53. 53.
    Yohn DS, Marmol FR, Olsen RG (1970) Growth kinetics of Yaba tumor poxvirus after in vitro adaptation to cercopithecus kidney cells. J Virol 5: 205–211PubMedGoogle Scholar
  54. 54.
    Yohn DS, Haendiges VA, Grace JT Jr (1966) Yaba tumor poxvirus synthesis in vitro. I. Cytopathological, histochemical, and immunofluorescent studies. J Bacteriol 91: 1977–1985Google Scholar
  55. 55.
    Tsuruhara T (1971) Immature particle formation of Yaba poxvirus studied by electron microscopy. J Natl Cancer Inst 47: 549–554PubMedGoogle Scholar
  56. 56.
    Dales S, Mosbach EH (1968) Vaccinia as a model for membrane biogenesis. Virology 35: 564–583PubMedCrossRefGoogle Scholar
  57. 57.
    Smith GL, Vanderplasschen A, Law M (2002) The formation and function of extracellular enveloped vaccinia virus. J Gen Virol 83: 2915–2931PubMedGoogle Scholar
  58. 58.
    Engelstad M, Smith GL (1993) The vaccinia virus 42-kDa envelope protein is required for the envelopment and egress of extracellular virus and for virus virulence. Virology 194: 627–637PubMedCrossRefGoogle Scholar
  59. 59.
    Wolffe EJ, Isaacs SN, Moss B (1993) Deletion of the vaccinia virus B5R gene encoding a 42-kilodalton membrane glycoprotein inhibits extracellular virus envelope formation and dissemination. J Virol 67: 4732–4741PubMedGoogle Scholar
  60. 60.
    Law M, Carter GC, Roberts KL, Hollinshead M, Smith GL (2006) Ligandinduced and nonfusogenic dissolution of a viral membrane. Proc Natl Acad Sci USA 103: 5989–5994PubMedCrossRefGoogle Scholar
  61. 61.
    Essani K, Chalasani S, Eversole R, Beuving L, Birmingham L (1994) Multiple anti-cytokine activities secreted from tanapox virus-infected cells. Microb Pathog 17: 347–353PubMedCrossRefGoogle Scholar
  62. 62.
    Paulose M, Bennett BL, Manning AM, Essani K (1998) Selective inhibition of TNF-alpha induced cell adhesion molecule gene expression by tanapox virus. Microb Pathog 25: 33–41PubMedCrossRefGoogle Scholar
  63. 63.
    Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G (2003) A secreted high-affinity inhibitor of human TNF from Tanapox virus. Proc Natl Acad Sci USA 100: 4831–4836PubMedCrossRefGoogle Scholar
  64. 64.
    Najarro P, Lee HJ, Fox J, Pease J, Smith GL (2003) Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1. J Gen Virol 84: 3325–3336PubMedCrossRefGoogle Scholar
  65. 65.
    Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL (2006) Yabalike disease virus chemokine receptor 7L, a CCR8 orthologue. J Gen Virol 87: 809–816PubMedCrossRefGoogle Scholar
  66. 66.
    Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL (2004) A new member of the interleukin 10-related cytokine family encoded by a poxvirus. J Gen Virol 85: 1401–1412PubMedCrossRefGoogle Scholar
  67. 67.
    Ha SC, Lokanath NK, Van Quyen D, Wu CA, Lowenhaupt K, Rich A, Kim YG, Kim KK (2004) A poxvirus protein forms a complex with left-handed Z-DNA: crystal structure of a Yatapoxvirus Zalpha bound to DNA. Proc Natl Acad Sci USA 101: 14367–14372PubMedCrossRefGoogle Scholar
  68. 68.
    Hu Y, Lee J, McCart JA, Xu H, Moss B, Alexander HR, Bartlett DL (2001) Yaba-like disease virus: an alternative replicating poxvirus vector for cancer gene therapy. J Virol 75: 10300–10308PubMedCrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Geoffrey L. Smith
    • 1
  1. 1.Department of Virology, Faculty of MedicineImperial College London, St. Mary’s CampusLondonUK

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