Gene transfer technology
In vivo gene transfer is a useful tool for generating animal models of disease, and for validating pathways that are involved in disease. The understanding that is gained through this technology can provide the information needed to develop new therapeutics specifically targeted at the pathways of interest. The choice of gene transfer vector will depend on the tissue and cell types to be transduced, the levels of gene expression needed, and the duration of gene expression. Recent advances in generating recombinant viral vectors, and the identification of new serotypes with different tropism, allow for the generation of a wide range of animal models.
KeywordsGene Transfer Recombinant Adenovirus Gene Transfer Vector Gene Transfer Technology Somatic Gene Transfer
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