United States guidelines and regulations in animal experimentation

  • Joanne B. Morris
  • Jeffrey Everitt
  • Margaret S. Landi
Part of the Progress in Inflammation Research book series (PIR)


The use of animals in biomedical research is a privilege granted by society, and the rules and regulations that govern this usage are in place to ensure the welfare of the laboratory animal subjects. The IACUC is the institutional commitment to this protection, and IACUC members continually challenge themselves and others to find a balance between achieving both scientific and animal welfare objectives. This is accomplished by incorporating the three Rs (reduction replacement and refinement) into animal usage in research, teaching and testing. IACUC members can be advocates for both the animals and the scientist. A good working relationship between the committee and the attending and/or laboratory animal veterinarian will promote identification, interpretation and clarification of the major rules and regulations. It is ultimately the responsibility of each investigator to comply with regulations for the welfare and safety of the animals and people involved in any research project. Animal models used in inflammation research often have specific considerations that need to be addressed to minimize issues of pain and distress. This includes the use of well-defined endpoints, the proper use of pharmacological interventions and the use of other pain-alleviating methods.


Animal Welfare Public Health Service Good Laboratory Practice Institutional Commitment Institutional Official 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Russell WMS, Burch RL (1959) The Principles of Humane Experimental Technique. Methuen, LondonGoogle Scholar
  2. 2.
    Institute for Laboratory Animal Research Journal (2002) Regulatory Testing and Animal Welfare. ILAR Online 43SupplementGoogle Scholar
  3. 3.
    Anderson LC (2002) Laws, regulations, and policies affecting the use of laboratory animals. In: J Fox, L Anderson, F Loew, F Quimby (eds): Laboratory Animal Medicine, 2nd edn. Academic Press, London, 19–32Google Scholar
  4. 4.
    Animal Welfare Act (Title 7 U.S.C. 2131-2159), as amended by P.L. 107–171 May 13, 2002.Google Scholar
  5. 5.
    Kulpa-Eddy JA, Taylor S, Adams KM (2005) USDA perspective on environmental enrichment for animals. ILAR 46(2): 83–94Google Scholar
  6. 6.
    US Department of Health and Human Services, National Institute of Health, Office of Laboratory Animal Welfare. Public Health Service Policy of Humane Care and Use of Laboratory Animals, revised August 2002, pursuant to Health Research Extension Act of 1985 (P.L. 99–158, November 20, 1985.)Google Scholar
  7. 7.
    National Research Council, Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington D.C.Google Scholar
  8. 8.
    Owiertniewicz J (2005) Introductions to the Good Laboratory Practice Regulations. Lab Animal 34(3): 29–32CrossRefGoogle Scholar
  9. 9.
    US Department of Health and Human Services, Food and Drug Administration (2005) Good Laboratory Practice for Non Clinical Laboratory Studies (21 CFR Part 58)Google Scholar
  10. 10.
    Olfert ED, Godson DL (2000) Humane Endpoints for Infectious Disease Animal Models. ILAR 41(2): 99–104Google Scholar
  11. 11.
    Morton DB (1998) Humane endpoints in animal experimentation for biomedical research: ethical, legal, and practical aspects. In: CFM Hendriksen, DB Morton (eds): Proceedings of the International Conference: Humane endpoints in animal experimentation for biomedical research, 22–25 Nov 1998, Zeist, The NetherlandsGoogle Scholar
  12. 12.
    Stasiak KL, Maul D, French E, Hellyer PW, Vandewoude S (2003) Species-specific assesment of pain in laboratory animals. Contemp Top 42(4): 13–20Google Scholar
  13. 13.
    National Institute of Health Office of Animal Care and Use (2005) ARAC Guidelines. Guidelines for Endpoints in Animal Study Proposals. Revised 1/12/05Google Scholar
  14. 14.
    Canadian Council on Animal Care (1998) Guidelines on: choosing an appropriate endpoint in experiments using animals for research, teaching and testing. Ottawa, CanadaGoogle Scholar
  15. 15.
    Institute for Laboratory Animal Research Journal (2000) Humane Endpoints for Animals Used in Biomedical Research and Testing. ILAR 41: 2Google Scholar
  16. 16.
    Freedom of Information Act (Title 5 of the United States Code, Section 552) as amended by P.L. No. 104–231, 110 Stat. 3048 March 31, 1997Google Scholar

Copyright information

© Birkhäuser Verlag Basel/Switzerland 2006

Authors and Affiliations

  • Joanne B. Morris
    • 1
  • Jeffrey Everitt
    • 1
  • Margaret S. Landi
    • 1
  1. 1.GlaxoSmithKline Pharmaceuticals, LASKing of PrussiaUSA

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