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The Resolution of Inflammation pp 57–73Cite as

Cell surface molecular changes associated with apoptosis

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Regulation of cellular responses to micro-environmental stimuli is achieved through cell surface receptors, which may assemble into complexes that permit the bi-directional transmission of information across the plasma membrane. It has been estimated that circulating lymphocytes may express several hundred different surface receptors [1], which may confer specificity for an equivalent number of extracellular cues. The expression and function of these critical portals of communication are thus extremely tightly regulated to ensure appropriate cellular responses, including altered adhesion and migration, activation and cellular proliferation. In this chapter we consider the changes in cell surface receptor profiles that are associated with programmed cell death or apoptosis, discussing the implications in terms of their influence upon cellular responses and upon processes that impact upon disease pathogenesis. Many studies of the process of apoptosis have been performed in vitro, using model systems in which cell death is initiated following chemical or radiation (e.g. ultraviolet) insult. Alternatively, apoptosis may be induced by ligation of death receptors leading to activation of the caspase cascade within the cell. Whether the changes observed in these in vitro systems mimic physiological death within tissues is uncertain, but for the purposes of this review, we assume that many of the changes that are initiated also occur on cells as they undergo apoptosis in situ.

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Authors and Affiliations

  1. MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, UK

    Ian Dransfield, Kim Wilkinson, Aisleen McColl & Simon P. Hart

  2. Institute for Immunology, FAU Erlangen-Nuremberg, Glückstrasse 4a, 91054, Erlangen, Germany

    Sandra Franz & Martin Herrmann

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  1. Ian Dransfield
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  2. Sandra Franz
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  3. Kim Wilkinson
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  4. Aisleen McColl
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  5. Martin Herrmann
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  6. Simon P. Hart
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Editors and Affiliations

  1. MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent Edinburgh, EH16 4TJ, Scotland, UK

    Adriano G. Rossi  & Deborah A. Sawatzky  & 

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Dransfield, I., Franz, S., Wilkinson, K., McColl, A., Herrmann, M., Hart, S.P. (2008). Cell surface molecular changes associated with apoptosis. In: Rossi, A.G., Sawatzky, D.A. (eds) The Resolution of Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7506-5_4

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