Cell surface molecular changes associated with apoptosis

  • Ian Dransfield
  • Sandra Franz
  • Kim Wilkinson
  • Aisleen McColl
  • Martin Herrmann
  • Simon P. Hart
Part of the Progress in Inflammation Research book series (PIR)


Regulation of cellular responses to micro-environmental stimuli is achieved through cell surface receptors, which may assemble into complexes that permit the bi-directional transmission of information across the plasma membrane. It has been estimated that circulating lymphocytes may express several hundred different surface receptors [1], which may confer specificity for an equivalent number of extracellular cues. The expression and function of these critical portals of communication are thus extremely tightly regulated to ensure appropriate cellular responses, including altered adhesion and migration, activation and cellular proliferation. In this chapter we consider the changes in cell surface receptor profiles that are associated with programmed cell death or apoptosis, discussing the implications in terms of their influence upon cellular responses and upon processes that impact upon disease pathogenesis. Many studies of the process of apoptosis have been performed in vitro, using model systems in which cell death is initiated following chemical or radiation (e.g. ultraviolet) insult. Alternatively, apoptosis may be induced by ligation of death receptors leading to activation of the caspase cascade within the cell. Whether the changes observed in these in vitro systems mimic physiological death within tissues is uncertain, but for the purposes of this review, we assume that many of the changes that are initiated also occur on cells as they undergo apoptosis in situ.


Apoptotic Cell Neutrophil Apoptosis Apoptotic Neutrophil Apoptotic Cell Clearance Golgi Fragmentation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Ian Dransfield
    • 1
  • Sandra Franz
    • 2
  • Kim Wilkinson
    • 1
  • Aisleen McColl
    • 1
  • Martin Herrmann
    • 2
  • Simon P. Hart
    • 1
  1. 1.MRC Centre for Inflammation ResearchUniversity of Edinburgh Medical SchoolEdinburghUK
  2. 2.Institute for ImmunologyFAU Erlangen-NurembergErlangenGermany

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