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Granulocyte apoptosis

  • Moira K. B. Whyte
  • Christopher Haslett
  • Edwin R. Chilvers
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Neutrophil apoptosis (programmed cell death) is now recognised to play a fundamental role in the physiological resolution of innate immune responses. Early work by Metchnikoff correlated the ingestion of microphages (neutrophils) by macrophages with the resolution of acute inflammation, but nearly 100 years elapsed before the key role of apoptosis in determining the lifespan of granulocytes and their clearance from sites of inflammation was described [1]. Further work showed that apoptosis leads to down-regulation of neutrophil pro-inflammatory functions [2] and this, together with evidence that macrophage clearance of apoptotic granulocytes was anti-inflammatory [3], suggested that apoptosis induction could be a powerful therapeutic strategy to “turn off” neutrophilic inflammation [2].

Keywords

Human Neutrophil Allergy Clin Immunol Chronic Granulomatous Disease Neutrophil Apoptosis Mitochondrial Outer Membrane Permeabilisation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Moira K. B. Whyte
    • 1
  • Christopher Haslett
    • 2
  • Edwin R. Chilvers
    • 3
  1. 1.Academic Unit of Respiratory Medicine, School of Medicine and Biomedical SciencesUniversity of Sheffield, Royal Hallamshire HospitalSheffieldUK
  2. 2.MRC Centre for Inflammation Research, Queen’s Medical Research InstituteUniversity of Edinburgh Medical SchoolEdinburghUK
  3. 3.Respiratory Medicine Division, Department of MedicineUniversity of Cambridge, School of Clinical Medicine, Addenbrooke’s and Papworth HospitalsCambridgeUK

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