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The Resolution of Inflammation pp 1–18Cite as

The resolution of acute inflammation: A ‘tipping point’ in the development of chronic inflammatory diseases

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Evolution has given us inflammation, a formidable ally in the constant battle against infection, cancer and tissue injury. It is a primordial response that protects against injury and restores damaged tissue to its normal physiological function. In fact, our well-being and survival depends upon its efficiency and carefully balanced control. In general, the innate inflammatory response initiates within minutes and, if all is well, resolves within hours. In contrast, chronic inflammation persists for weeks, months or even years. Here, we are going to discuss the key endogenous checkpoints necessary for mounting an effective, yet limited, inflammatory response and the crucial biochemical pathways necessary to prevent its persistence. Figure 1 depicts what we understand today about the endogenous soluble mediators that control the severity of inflammatory onset as well as its longevity. In doing so, we wish to underline the consequence to the host of failing to adequately control inflammatory resolution.

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Author information

Authors and Affiliations

  1. Rayne Institute, Centre for Clinical Pharmacology, University College London, 5 University Street, London, WC1 6JJ, UK

    Derek Gilroy

  2. Institute of Cancer, Centre for Translational Oncology, Bart’s and The London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK

    Toby Lawrence

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  1. Derek Gilroy
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  2. Toby Lawrence
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Editors and Affiliations

  1. MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent Edinburgh, EH16 4TJ, Scotland, UK

    Adriano G. Rossi  & Deborah A. Sawatzky  & 

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© 2008 Birkhäuser Verlag Basel/Switzerland

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Gilroy, D., Lawrence, T. (2008). The resolution of acute inflammation: A ‘tipping point’ in the development of chronic inflammatory diseases. In: Rossi, A.G., Sawatzky, D.A. (eds) The Resolution of Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7506-5_1

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