Since the question: “Can dietary β-carotene materially affect cancer rates?” first surfaced in 1981 , a large research effort has been directed to trying to determine if this is indeed the case. Much of the work has been based on the premise that any effect is likely to involve antioxidant action (Chapter 12) or effects on cellular and molecular processes (Chapter 11). The participation of the immune response system (Chapter 17) and suggestions that effects attributed to carotenoids may be mediated via retinoids or other metabolites/breakdown products (Chapter 18) have also attracted much attention. A variety of experimental approaches have been used to investigate the relationship between carotenoids and the incidence of cancer (Chapter 13) or coronary heart disease (CHD) (Chapter 14), particularly human, animal and cell studies. With the eye (Chapter 15) and skin (Chapter 16), the situation is different. These tissues are exposed to high intensity light, that can lead to photodamage. Do carotenoids have any protective roles against this damage?
KeywordsCoronary Heart Disease Carotenoid Concentration Immune Response System Accelerator Mass Spectrometry Food Composition Table
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