Carotenoids pp 211-234 | Cite as

Modulation of Intracellular Signalling Pathways by Carotenoids

  • Paola Palozza
  • Simona Serini
  • Maria Ameruso
  • Sara Verdecchia
Part of the Carotenoids book series (CAROT, volume 5)


Cancer and cardiovascular disease are the most common causes of death in developed countries. A high dietary intake of fruits and vegetables has been associated with a decreased risk of developing such chronic diseases [1,2]. It has been suggested that carotenoids may play a key role in these beneficial effects of fruit and vegetable consumption. Some observational epidemiological studies (Chapters 10, 13 and 14) have indicated that carotenoids may act as protective agents against some lung cancers and a variety of other chronic diseases [3]. These epidemiological data have been supported by several studies performed in vivo and in vitro [4, 5, 6] in which inhibitory effects of carotenoids on tumour growth and cardiovascular diseases have been observed. Some intervention trials, though, in which β-carotene (3) was administered as a supplement to individuals at high risk, such as smokers and asbestos workers, have shown no preventive effects or indeed have indicated enhanced incidence of lung cancer [7,8]. In others, however, supplementation with β-carotene was reported to exert beneficial effects [9].


Retinoic Acid Reactive Oxygen Species Production Intracellular Signalling Pathway Constitutive Androstane Receptor Carotenoid Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel 2009

Authors and Affiliations

  • Paola Palozza
    • 1
  • Simona Serini
    • 1
  • Maria Ameruso
    • 1
  • Sara Verdecchia
    • 1
  1. 1.School of MedicineInstitute of General Pathology Catholic UniversityRomeItaly

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