Carotenoids pp 191-210 | Cite as

Epidemiology and Intervention Trials

  • Susan T. Mayne
  • Margaret E. Wright
  • Brenda Cartmel
Part of the Carotenoids book series (CAROT, volume 5)


Determining the health effects of carotenoids in humans is a challenging yet high priority area of research. Epidemiology is the study of the distribution and determinants of disease in human populations. Epidemiologists who study carotenoids are thus interested in determining if carotenoid intake or carotenoid status is associated with risk of various disease endpoints. As carotenoids are known to have antioxidant functions in plants, and evidence suggests that oxidative stress could be involved in the aetiology of chronic diseases such as cancer, heart disease, cataract and macular degeneration, much of the epidemiological research on carotenoids has emphasized links with risk of these and other chronic diseases, as summarized in Chapters 13–15.


Food Frequency Questionnaire Vegetable Intake Lung Cancer Risk Carotenoid Concentration European Prospective Investigation Into Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    National Academy of Sciences, Institute of Medicine, Food and Nutrition Board, Panel on Micronutrients, Dietary Reference. Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, National Academy Press, Washington, D.C. (2001).Google Scholar
  2. [2]
    National Academy of Sciences, Institute of Medicine, Food and Nutrition Board, Panel on Dietary Antioxidants and Related Compounds, Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids, National Academy Press, Washington, D.C. (2000).Google Scholar
  3. [3]
    S. T. Mayne, B. Cartmel, M. Baum, G. Shor-Posner, B. G. Fallon, K. Briskin, J. Bean, T. Zheng, D. Cooper, C. Friedman and W. J. Goodwin Jr., Cancer Res., 61, 1457 (2001).Google Scholar
  4. [4]
    C. H. Hennekens, J. E. Buring, J. E. Manson, M. Stampfer, B. Rosner, N. R. Cook, C. Belanger, F. LaMotte, J. M. Gaziano, P. M. Ridker, W. Willett and R. Peto, N. Engl. J. Med., 334, 1145 (1996).CrossRefGoogle Scholar
  5. [5]
    C. L. Rock, S. W. Flatt, F. A. Wright, S. Faerber, V. Newman, S. Kealey and J. P. Pierce, Cancer Epidemiol. Biomarkers Prev., 6, 617 (1997).Google Scholar
  6. [6]
    E. Lanza, A. Schatzkin, C. Daston, D. Corle, L. Freedman, R. Ballard-Barbash, B. Caan, P. Lance, J. Marshall, F. Iber, M. Shike, J. Weissfeld, M. Slattery, E. Paskett, D. Mateski and P. Albert, Am. J. Clin. Nutr., 74, 387 (2001).Google Scholar
  7. [7]
    L. Chen, M. Stacewicz-Sapuntzakis, C. Duncan, R. Sharifi, L. Ghosh, R. van Breemen, D. Ashton and P. E. Bowen, J. Natl. Cancer Inst., 93, 1872 (2001).CrossRefGoogle Scholar
  8. [8]
    C. S. You, R. S. Parker and J. E. Swanson, Asia Pac. J. Clin. Nutr., 11 Suppl, S438 (2002).CrossRefGoogle Scholar
  9. [9]
    N. M. Zagre, F. Delpeuch, P. Traissac and H. Delisle, Public Health Nutr., 6, 733 (2003).CrossRefGoogle Scholar
  10. [10]
    S. T. Mayne, B. Cartmel, F. Silva, C. S. Kim, B. G. Fallon, K. Briskin, T. Zheng, M. Baum, G. Shor-Posner and W. J. Goodwin Jr., J. Nutr., 129, 849 (1999).Google Scholar
  11. [12]
    A. R. Mangels, J. M. Holden, G. R. Beecher, M. R. Forman and E. Lanza, J. Am. Diet. Assoc., 93, 284 (1993).CrossRefGoogle Scholar
  12. [14]
    A. R. Kristal, U. Peters and J. D. Potter, Cancer Epidemiol. Biomarkers Prev., 14, 2826 (2005).CrossRefGoogle Scholar
  13. [15]
    L. F. Andersen, M. B. Veierod, L. Johansson, A. Sakhi, K. Solvoll and C. A. Drevon, Br. J. Nutr., 93, 519 (2005).CrossRefGoogle Scholar
  14. [16]
    E. Riboli, J. Nutr., 131, 170S (2001).Google Scholar
  15. [17]
    A. F. Subar, V. Kipnis, R. P. Troiano, D. Midthune, D. A. Schoeller, S. Bingham, C. O. Sharbaugh, J. Trabulsi, S. Runswick, R. Ballard-Barbash, J. Sunshine and A. Schatzkin, Am. J. Epidemiol., 158, 1 (2003).CrossRefGoogle Scholar
  16. [18]
    A. F. Kardinaal, P. Van’t Veer, H. A. Brants, H. van den Berg, J. van Schoonhoven and R. J. Hermus, Am. J. Epidemiol., 141, 440 (1995).Google Scholar
  17. [19]
    K. J. Yeum, S. H. Ahn, S. A. Rupp de Paiva, Y. C. Lee-Kim, N. I. Krinsky and R. M. Russell, J. Nutr., 128, 1920 (1998).Google Scholar
  18. [20]
    T. R. Hata, T. A. Scholz, I. V. Ermakov, R. W. McClane, F. Khachik, W. Gellermann and L. K. Pershing, J. Invest. Dermatol., 115, 441 (2000).CrossRefGoogle Scholar
  19. [21]
    S. T. Mayne, B. Cartmel, S. Scarmo, H. Lin, D. J. Lefell, I. Ermakov, P. Bhosale, P. S. Bernstein and W. Gellermann, Abstr. 15th Int. Symp. Carotenoids, Okinawa, 2008, Carotenoid Sci., 12, 54 (2008).Google Scholar
  20. [22]
    W. Stahl, U. Heinrich, H. Jungmann, J. von Laar, M. Schietzel, H. Sies and H. Tronnier, J. Nutr., 128, 903 (1998).Google Scholar
  21. [23]
    M. A. Eastwood, QJM: An International Journal of Medicine, 92, 527 (1999).Google Scholar
  22. [24]
    M. E. Wright, S. T. Mayne, R. Z. Stolzenberg-Solomon, Z. Li, P. Pietinen, P. R. Taylor, J. Virtamo and D. Albanes, Am. J. Epidemiol., 160, 68 (2004).CrossRefGoogle Scholar
  23. [25]
    M. E. Wright, S. T. Mayne, C. A. Swanson, R. Sinha and M. C. Alavanja, Cancer Causes Control, 14, 85 (2003).CrossRefGoogle Scholar
  24. [26]
    P. Knekt, R. Jarvinen, L. Teppo, A. Aromaa and R. Seppanen, J. Natl. Cancer Inst., 91, 182 (1999).CrossRefGoogle Scholar
  25. [27]
    L. Le Marchand, J. H. Hankin, L. N. Kolonel, G. R. Beecher, L. R. Wilkens and L. P. Zhao, Cancer Epidemiol. Biomarkers Prev., 2, 183 (1993).Google Scholar
  26. [28]
    J. Dallongeville, N. Marecaux, J. C. Fruchart and P. Amouyel, J. Nutr., 128, 1450 (1998).Google Scholar
  27. [29]
    G. S. Omenn, G. E. Goodman, M. D. Thornquist, J. Balmes, M. R. Cullen, A. Glass, J. P. Keogh, F. L. Meyskens, B. Valanis, J. H. Williams, S. Barnhart and S. Hammar, N. Engl. J. Med., 334, 1150 (1996).CrossRefGoogle Scholar
  28. [30]
    The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group, N. Engl. J. Med., 330, 1029 (1994).CrossRefGoogle Scholar
  29. [31]
    W. J. Blot, J. Y. Li, P. R. Taylor, W. Guo, S. Dawsey, G. Q. Wang, C. S. Yang, S. F. Zheng, M. Gail, G. Y. Li, Y. Yu, B. Q. Liu, J. Tangrea, Y. H. Sun, F. Liu, J. F. Fraumeni Jr., Y. H. Zhang and B. Li, J. Natl. Cancer Inst., 85, 1483 (1993).CrossRefGoogle Scholar
  30. [32]
    S. Hercberg, P. Galan, P. Preziosi, S. Bertrais, L. Mermen, D. Malvy, A. M. Roussel, A. Favier and S. Bnancon, Arch. Intern. Med., 164, 2335 (2004).CrossRefGoogle Scholar
  31. [33]
    J. A. Baron, B. F. Cole, L. Mort, R. Haile, M. Grau, T. R. Church, G. J. Beck and E. R. Greenberg, J. Natl. Cancer Inst., 95, 717 (2003).CrossRefGoogle Scholar
  32. [34]
    S. T. Mayne and S. M. Lippman, J. Natl. Cancer Inst., 97, 1319 (2005).Google Scholar
  33. [35]
    D. Albanes and M. Wright, in Carotenoids in Health and Disease (ed. N. Krinsky, S. Mayne and H. Sies), p. 531, Marcel Dekker, New York (2004).Google Scholar
  34. [36]
    S. Mayne and B. Cartmel, Cancer Epidemiol. Biomarkers Prev., 15, 2033 (2006).CrossRefGoogle Scholar
  35. [37]
    E. R. Greenberg, J. A. Baron, T. A. Stukel, M. M. Stevens, J. S. Mandel, S. K. Spencer, P. M. Elias, N. Lowe, D. W. Nierenberg, G. Bayrd, J. C. Vance, D. H. Freeman Jr., W. E. Clenderming, T. Kwan and the Skin Cancer Prevention Study Group, N. Engl. J. Med., 323, 789 (1990).Google Scholar
  36. [38]
    AREDS Report number 8, Arch. Ophthalmol., 119, 1417 (2001).Google Scholar
  37. [39]
    S. Mayne, B. Cartmel and D. Morse, in Head and Neck Cancer: Emerging Perspectives (ed. J. F. Ensley, J. S. Gutkind, J. R. Jacobs and S. M. Lippman), p. 261, Academic Press, New York (2003).Google Scholar
  38. [40]
    T. W. Boileau, Z. Liao, S. Kim, S. Lemeshow, J. W. Erdman Jr. and S. K. Clinton, J. Natl. Cancer Inst., 95, 1578 (2003).Google Scholar

Copyright information

© Birkhäuser Verlag Basel 2009

Authors and Affiliations

  • Susan T. Mayne
    • 1
  • Margaret E. Wright
    • 2
  • Brenda Cartmel
    • 3
  1. 1.Yale School of Public HeathNew HavenUSA
  2. 2.Department of Pathology College of MedicineUniversity of Illinois at ChicagoChicagoUSA
  3. 3.Yale School of Public HealthNew HavenUSA

Personalised recommendations