Small molecule CCR2 antagonists
Monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. During inflammatory conditions, the production of MCP-1 is upregulated in both immune and non-immune cell types including macrophages, mast cells, fibroblasts, endothelial and epithelial cells, smooth muscle cells, and astrocytes. MCP-1 is a potent activator and chemoattractant of leukocytes such as monocytes, macrophages, activated T cells, dendritic cells, and natural killer (NK) cells . The biological effects of MCP-1 are mediated by interaction with its primary receptor, CCR2. In addition to inducing chemotaxis, other cellular responses induced by MCP-1 include integrin activation, inflammatory cytokine production, and histamine release [2, 3].
KeywordsChronic Obstructive Pulmonary Disease Acquire Immune Deficiency Syndrome CCR2 Antagonist Allergic Asthmatic Patient Chemokine Receptor Antagonist
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