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Small molecule CCR2 antagonists

  • Paul J. Higgins
  • C. Eric Schwartz
  • Jean-Marie Nicolas
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. During inflammatory conditions, the production of MCP-1 is upregulated in both immune and non-immune cell types including macrophages, mast cells, fibroblasts, endothelial and epithelial cells, smooth muscle cells, and astrocytes. MCP-1 is a potent activator and chemoattractant of leukocytes such as monocytes, macrophages, activated T cells, dendritic cells, and natural killer (NK) cells [1]. The biological effects of MCP-1 are mediated by interaction with its primary receptor, CCR2. In addition to inducing chemotaxis, other cellular responses induced by MCP-1 include integrin activation, inflammatory cytokine production, and histamine release [2, 3].

Keywords

Chronic Obstructive Pulmonary Disease Acquire Immune Deficiency Syndrome CCR2 Antagonist Allergic Asthmatic Patient Chemokine Receptor Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Paul J. Higgins
    • 1
  • C. Eric Schwartz
    • 1
  • Jean-Marie Nicolas
    • 1
  1. 1.UCB Research/UCB PharmaCambridgeUSA

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