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Chemokine axes in hematopoietic stem cell mobilization

  • Louis M. Pelus
  • Hal E. Broxmeyer
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Under steady state, hematopoietic cells at all stages of differentiation and some lymphoid cell populations are confined within the bone marrow, while mature cells exit and enter peripheral blood. A small population of hematopoietic stem (HSC) and progenitor (HPC) cells also traffic through the peripheral circulation. The initial observations that HPC cells are found in the blood of patients recovering from chemotherapy [1, 2, 3] led to the realization that HSC and HPC can be forced or ‘mobilized’ from marrow to blood where they can be collected by apheresis and utilized for transplantation [4].

Keywords

Peripheral Blood Stem Cell Hematopoietic Progenitor Cell Stem Cell Mobilization CXCR4 Antagonist Rapid Mobilization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Louis M. Pelus
    • 1
  • Hal E. Broxmeyer
    • 1
  1. 1.Department of Microbiology & Immunology and the Walther Oncology CenterIndiana University School of Medicine and the Walther Cancer InstituteIndianapolisUSA

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