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Chemokines in animal models of inflammation

  • Steven L. Kunkel
  • Nuria Godessart
  • Cory Hogaboam
  • Stephen W. Chensue
  • Nicholas Lukacs
Part of the Progress in Inflammation Research book series (PIR)

Abstract

There is little doubt that animal modeling of various human diseases, disorders, and toxicology has been a staple of both academia and the pharmaceutical industry for decades. While it may be difficult to argue that experimental models, in particular rodent models, of human disease provide an exact mimic of their human counterpart, these experimental systems do provide a mechanism to generate meaningful data in the absence of human specimens. This is especially true in the case of human inflammatory disease where one is unlikely to gain access to tissue samples during the early initiation of a disease, and in the case of chronic disease where continuous, longitudinal samples are nearly impossible to obtain to assess the maintenance stage of chronic disease. Thus, the strategic use of experimental animal systems will continue to be an important tool in assessing both mechanisms of disease and efficacy of drugs which target these diseases.

Keywords

Chemokine Receptor Adult Respiratory Distress Syndrome Foreign Agent Specific Chemokines Chemokine Receptor Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Steven L. Kunkel
    • 1
  • Nuria Godessart
    • 3
  • Cory Hogaboam
    • 1
  • Stephen W. Chensue
    • 1
    • 2
  • Nicholas Lukacs
    • 1
  1. 1.Department of PathologyThe University of Michigan Medical SchoolAnn ArborUSA
  2. 2.The University of Michigan Medical and Veterans Administration HospitalAnn ArborUSA
  3. 3.Almirall Research CenterSant Feliu de LlobregatSpain

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