Influencing energy expenditure and substrate utilisation

  • John C. Clapham
  • Jonathan R. Arch
Part of the Milestones in Drug Therapy book series (MDT)


Most of the anti-obesity drugs used over the past 50 years, and one (sibutramine) of the two globally licensed for long-term use today have acted centrally. With the exception of sibutramine (and the possible further approval of rimonabant), however, all of these have been withdrawn due to concerns over toxicity or abuse potential, or their use is greatly restricted. This is one reason why pharmaceutical companies are seeking drugs that act peripherally to influence energy expenditure, substrate utilisation or both. Fortunately, studies on genetically modified mice are revealing many new targets that fall into these categories [1].


Mitochondrial Biogenesis Triacylglycerol Synthesis Anorectic Drug Anorectic Agent Expert Opin Investig Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag/Switzerland 2008

Authors and Affiliations

  • John C. Clapham
    • 1
  • Jonathan R. Arch
    • 2
  1. 1.CVG I BioscienceAstra ZenecaMacclesfieldUK
  2. 2.Clore LaboratoryUniversity of BuckinghamBuckinghamUK

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