Some historical aspects of drug treatment for obesity

  • George A. Bray
Part of the Milestones in Drug Therapy book series (MDT)


Janus was the Roman god with two faces — one face smiling, one scowling [2, 3]. He is frequently seen as the symbol for theater — tragedy and comedy being his two faces. Amphetamine, the first drug with a clinical trial showing effectiveness in the battle of the bulge, also has two faces. One face was suppression of appetite, the other face was addiction. It was this latter frowning face that has cast a cloud of doubt and concern over pharmacological agents developed to help in the battle of the bulge. This is the story.


Thyroid Hormone Thyroid Gland Valvular Heart Disease Reduce Food Intake Historical Aspect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag/Switzerland 2008

Authors and Affiliations

  • George A. Bray
    • 1
  1. 1.Pennington Biomedical Research CenterBaton RougeUSA

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