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Significance of the Inflammatory Response in Brain Ischemia

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Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 66))

Summary

Leukocytes appear to have a central role in the inflammatory response that develops during acute brain ischemia. This brief review adduces evidence that leukocytes accumulate in focal zones of acute brain ischemia at a sufficiently early stage to participate in the process of progressive ischemic brain damage and that partial inhibition of that accumulation, by various measures, can attenuate ischemic brain injury. Mechanisms of leukocyte adhesion are discussed in detail and an inference is put forward that leukocytes are an important factor in progressive ischemic injury, but almost certainly act in concert with a number of other similarly important factors. On this basis, leukocyte inhibition may have demonstrable benefit in acute stroke, but ultimately be found to only partially spare potentially salvageable tissue in the ischemic zone.

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Author information

Authors and Affiliations

  1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 4A03, 36 Convent Drive MSC 4128, Bethesda, Maryland, 20892-4128, USA

    John M. Hallenbeck M.D.

Authors
  1. John M. Hallenbeck M.D.
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Editor information

Editors and Affiliations

  1. Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann  & Nikolaus Plesnila  & 

  2. Institut für Neurochirurgische Pathophysiologie, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany

    Oliver S. Kempski

  3. Klinik für Neurochirurgie, Universität zu Köln, Köln, Federal Republic of Germany

    Frank Staub

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© 1996 Springer-Verlag

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Hallenbeck, J.M. (1996). Significance of the Inflammatory Response in Brain Ischemia. In: Baethmann, A., Kempski, O.S., Plesnila, N., Staub, F. (eds) Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma. Acta Neurochirurgica, vol 66. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9465-2_5

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  • DOI: https://doi.org/10.1007/978-3-7091-9465-2_5

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9467-6

  • Online ISBN: 978-3-7091-9465-2

  • eBook Packages: Springer Book Archive

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