Summary
Studies of retrograde changes in axotomized motoneurons have revealed fundamental changes in morphology, metabolism and physiology of these cells. Restructuring of the granular endoplasmic reticulum, s.c. chromatolysis, seems to be the basis for increased and modified protein synthesis. While cytoskeletal proteins with the exception of the neurofilament triplet go up, enzymes and receptors related to neurotransmission go down and new growth associated proteins appear. There is an enhanced glucose uptake and iron metabolism. Complex changes in axonal transport have been observed. This may reflect the efforts of the regenerating nerve cell to compensate for its lost axon.
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References
Banati RB, Gehrmann J, Schubert P, Kreutzberg GW (1993) Cytoxicity of microglia. Glia 7: 111–118
Dumoulin FL, Raivich G, Haas CA, Lazar P, Reddington M, Streit WJ, Kreutzberg GW (1992) Calcitonin gene-related peptide and peripheral nerve regeneration. Ann NY Acad Sci 657: 351–360
Gehrmann J, Kreutzberg GW (1991) Characterisation of two new monoclonal antibodies directed against rat microglia. J Comp Neurol 313: 409–430
Haas CA, Donath C, Kreutzberg GW (1993) Differential expression of immediate early genes after transection of the facial nerve. Neuroscience 53: 91–99
Kiefer R, Lindholm D, Kreutzberg GW (1993) Interleukin-6 and transforming growth factor-ßl mRNAs are induced in rat facial nucleus following motoneuron axotomy. Eur J Neurosci 5: 775–781
Kreutzberg GW (1993) Perineuronal glial reactions in regeneration of motoneurons. In: Fedoroff S, Juurlink BHJ, Doucette R (eds) Biology and pathology of astrocyte-neuron interactions. Altschul Symposia, vol 2. Plenum, New York, pp 283–290
Moneta ME, Gehrmann J, Töpper R, Banati RB Kreutzberg GW (1993) Cell adhesion molecule expression in the regenerating rat facial nucleus. J Neuroimmunol 45: 203–206
Raivich G, Gehrmann J, Kreutzberg GW (1991) Increase of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor receptors in the regenerating rat facial nucleus. J Neurosci Res 30: 682–686
Raivich G, Kreutzberg GW (1994) Pathophysiology of glial growth factor receptors. Glia 11: 129–146
Sendtner M, Kreutzberg GW, Thoenen H (1990) Ciliary neurotrophic factor prevents the degeneration of motoneurons after axotomy. Nature 345: 440–441
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© 1996 Springer-Verlag
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Kreutzberg, G.W. (1996). Principles of Neuronal Regeneration. In: Baethmann, A., Kempski, O.S., Plesnila, N., Staub, F. (eds) Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma. Acta Neurochirurgica, vol 66. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9465-2_18
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DOI: https://doi.org/10.1007/978-3-7091-9465-2_18
Publisher Name: Springer, Vienna
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