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Environmental Influence on Outcome After Experimental Brain Infarction

  • Conference paper
Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 66))

  • 126 Accesses

Summary

After permanent ligation of the middle cerebral artery the motor function of rats housed in an enriched environment, i.e. cages with opportunities for various activities but not forcing the rats to do any particular task, is significantly better than in rats housed in individual cages. Rats kept in an enriched environment before and after MCA ligation improved sooner and slightly more than those placed in the enriched environment after ischemia but with no lasting significant difference except for climbing. Preliminary studies suggest that social stimulation is more important than physical activity. Rats with fetal neocortical grafts implanted into the infarct cavity performed better if exposed to enriched environment than grafted control rats housed in standard laboratory cages with 5 rats in each cage. However, they did not perform better than non-grafted rats housed in the same enriched environment. The infarct size did not differ between rats housed in an enriched environment and control rats. There was no correlation between infarct size and performance in rats exposed to an enriched environment. The improved motor function suggests that a rich environment may stimulate mechanisms that enhance brain plasticity.

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Authors and Affiliations

  1. Department of Neurology, Lund University Hospital, S-221 85, Lund, Sweden

    Barbro Johansson M.D.

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  1. Barbro Johansson M.D.
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Editors and Affiliations

  1. Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann  & Nikolaus Plesnila  & 

  2. Institut für Neurochirurgische Pathophysiologie, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany

    Oliver S. Kempski

  3. Klinik für Neurochirurgie, Universität zu Köln, Köln, Federal Republic of Germany

    Frank Staub

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© 1996 Springer-Verlag

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Johansson, B. (1996). Environmental Influence on Outcome After Experimental Brain Infarction. In: Baethmann, A., Kempski, O.S., Plesnila, N., Staub, F. (eds) Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma. Acta Neurochirurgica, vol 66. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9465-2_11

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  • DOI: https://doi.org/10.1007/978-3-7091-9465-2_11

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9467-6

  • Online ISBN: 978-3-7091-9465-2

  • eBook Packages: Springer Book Archive

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