Summary
From 8/90 through 4/94, 32 consecutive patients with recurrent pituitary macroadenoma (PA) were treated with LINAC-RS after tumour resection and/or radiotherapy. Single doses ranging from 8–20 Gy (median: 14.5 Gy) were applied in 14 patients with acromegaly, 5 with Cushing’s disease, 4 with Nelson tumours, 5 with prolactinomas and in 4 with nonfunctioning PA’s. Retrospective analysis of 26 patients with a follow-up of ≥ 6 months revealed no significant endocrinologic response in patients with Cushing’s disease, Nelson tumour or prolactinoma. In contrast in 12 evaluated patients with acromegaly within 6–36 months after LINAC-RS the median GH- value decreased significantly. In 3 nonfunctioning PA’s a tumour volume reduction has been observed. We conclude, that LINAC-RS with moderate single doses might be a safe and beneficial treatment in patients with acromegaly or nonfunctioning PA’s resistant to conventional therapy. In Cushing’s disease, Nelson tumours or prolactinomas higher doses seem to be required.
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© 1996 Springer-Verlag
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Voges, J. et al. (1996). LINAC-Radiosurgery (LINAC-RS) in Pituitary Adenomas: Preliminary Results. In: Fahlbusch, R., Bock, W.J., Brock, M., Buchfelder, M., Klinger, M. (eds) Modern Neurosurgery of Meningiomas and Pituitary Adenomas. Acta Neurochirurgica, vol 65. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9450-8_13
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DOI: https://doi.org/10.1007/978-3-7091-9450-8_13
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