Zusammenfassung
Der erste Schritt zur Aufklärung genetisch (mit) bedingter Erkrankungen besteht in der Lokalisation ätiologisch relevanter Gene im Genom. Bei genetisch komplexen Erkrankungen, wie z. B. den Psychosen, kann nur die gleichzeitige Anwendung verschiedener Kartierungsstrategien zum Erfolg führen. Zwar konnte weder in Kopplungs- noch in Assoziationsstudien für die Psychosen bisher ein Genort replizierbar lokalisiert werden. Trotzdem ist aufgrund der in den letzten Jahren erzielten Fortschritte bei anderen genetisch komplexen Erkrankungen damit zu rechnen, daß auch bei den psychotischen Erkrankungen in der nächsten Zeit ätiologisch relevante Gene lokalisiert werden können.
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Körner, J., Nöthen, M., Rietschel, M., Möller, HJ., Propping, P. (1996). Neuere Ergebnisse molekulargenetischer Untersuchungen bei psychotischen Erkrankungen. In: Möller, HJ., Deister, A. (eds) Vulnerabilität für affektive und schizophrene Erkrankungen. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9414-0_8
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