Abstract
Fungi are organisms widely distributed in nature and particularly abundant in soils, damp environments and in bad rests of foodstuffs. They encompass the most various forms of life (unicellular, multicellular, spherical, filamentous, parasitic, saprobic, symbiotic, etc.) and are often considered to be harmful, pathogenic or even toxic. Nevertheless fungi possess, besides their ecological importance as destruents (in connection with the decomposition of organic materials), also a great utility as producers of pharmacologically and commercially valuable natural substances. Indeed intensive research over the past five decades has shown that soil derived fungi, and above all those assigned to the class of Deuteromycetes (Fungi imperfecti), represent a rich source of bioactive secondary metabolites.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Nicot, J., and J. Meyer: Un Hyphomycète nouveau des sols tropicaux. Bulletin trimestriel de la Société mycologique de France, 72, 318 (1956).
Peter, H., and J. Auden: Deutsche Offenlegungsschrift, DE 35 22 578 Al (2.1.1986). i.
Sandmeier, p., and Ch. Tamm: Studies on the Biosynthesis of Spirostaphylotrichin A. Helv. Chim. Acta, 72, 774 (1989).
Sandmeier, P., and Ch. Tamm: New Spirostaphylotrichins from Staphylotrichum coccosporum. Helv. Chim. Acta, 72, 784 (1989).
Sandmeier, P., and Ch. Tamm: New Spirostaphylotrichins from the Mutant Strain P 84 of Staphylotrichum coccosporum. Helv. Chim. Acta, 72, 1107 (1989).
Sandmeier, P., and Ch. Tamm: New Spirostaphylotrichins from the Mutant Strain P 649 of Staphylotrichum coccosporum: The Biogenetic Interrelationship of the Known Spirostaphylotrichins. Helv. Chim. Acta, 73, 975 (1990).
Sugawara, F., N. Takahashi, G.A. Strobel, S.A. Strobel, H.S.M. Lu, and J. Clardy: Triticones A and B, Novel Phytotoxins from the Plant Pathogenic Fungus Drechslera tritici-repentis. J. Am. Chem. Soc., 110, 4086 (1988).
Hallock, Y.F., H.S.M. Lu, J. Clardy, G.A. Strobel, F. Sugawara, R. Samsoedin, and S. Yoshida: Triticones, Spirocyclic Lactams from the Fungal Plant Pathogen Drechslera tritici-repentis. J. Nat. Prod., 56, 747 (1993).
Ayer, W.A., P.A. Craw, and J. Neary: Metabolites of the Fungus Arthropsis truncata. Can. J. Chem., 70, 1338 (1992).
Ayer, W.A., and P.A. Craw: Biosynthesis and Biogenetic Interrelationships of the Metabolites of the Fungus Arthropsis truncata. Can. J. Chem., 70, 1348 (1992).
Probst, A., and Ch. Tamm: Biosynthesis of the Cytochalasans. Biosynthetic Studies on Chaetoglobosin A and 19-O-Acetylchaetoglobosin A. Helv. Chim. Acta, 64, 2065 (1981).
Möhr, P., and Ch. Tamm: Biosynthesis of Pseurotin A, Tetrahedron, 37, 201 (1981).
Kahana, Z.E., and A. Lapidot: Biosynthesis of Aspartic Acid and Alanine by Immobilized Bacteria. Anal. Biochem., 126, 389 (1982).
Mueller, B., A. Haedener, and Ch. Tamm: Studies on the Biosynthesis of Tabtoxin (Wildfire Toxin). Origin of the Carbonyl C-Atom of the ß-Lactam Moiety from the Ci-Pool. Helv. Chim. Acta, 70, 412 (1987).
O’Hagan, D.: Biosynthesis of Polyketide MetaboHtes. Nat. Prod. Reports, 8, 573 (1991).
Hopwood, D.A., and C. Khosla: Genes for Polyketide Secondary Metabolic Pathways in Microorganisms and Plants. In: Secondary Metabohtes: Their Function and Evolution (Ciba Foundation Symposium, 171), p. 88. Chichester-New York: Wiley. 1992.
Cane, D.E., and C.C. Yang: Macrolide Biosynthesis. Intact Incorporation of a Chain-Elongation Intermediate into Erythromycin. J. Am. Chem. Soc., 109, 1255 (1987).
Cane, D.E., P.C. Prabhakaran, W. Tan, and W.R. Ott: Macrolide Biosynthesis. Mechanism of Polyketide Chain Elongation. Tetrahedron Lett., 32, 5457 (1991).
Donadío, S., M.J. Staver, J.B. McAlpine, S.J. Swanson, and L. Katz: Modular Organization of Genes Required for Complex Polyketide Biosynthesis. Science, 252, 675 (1991).
Cane, D.E., R.H. Lambalot, P.C. Prabhakaran, and W.R. Ott: Incorporation of Polyketide Chain Elongation Intermediates into Methymycin. J. Am. Chem. Soc., 115, 522 (1993).
Yue, S., J.S. Duncan, Y. Yamamoto, and C.R. Hutchinson: Macrohde Biosynthesis. Tylactone Formation Involves the Processive Addition of Three Carbon Units. J. Am. Chem. Soc., 109, 1253 (1987).
Cane, D.E., W. Tan, and W.R. Ott: Nargenin Biosynthesis. Incorporation of Polyketide Chain Elongation Intermediates and Support for a Proposed Intermolecular Diels-Alder Cyclization. J. Am. Chem. Soc., 115, 527 (1993).
Patzelt, H., and J.A. Robinson: Biosynthesis of the Polyether Antibiotic Monensin A: Incorporation of a Polyketide Chain Elongation Intermediate. J. Chem. Soc., Chem. Commun., 16, 1258 (1993).
Hailes, H.C., C.M. Jackson, P.F. Leadlay, S.V. Ley, and J. Staunton: Biosynthesis of Tetronasin, Part 1: Introduction and Investigation of the Diketide and Triketide Intermediates Bound to the Polyketide Synthase. Tetrahedron Lett., 35, 307 (1994).
Hailes, H.C., H. Sandeep, F. Leadlay, I.C. Lennon, S.V. Ley, and J. Staunton: Biosynthesis of Tetronasin, Part 2: Identification of the Tetraketide Intermediate Attached to the Polyketide Synthase. Tetrahedron Lett., 35, 311 (1994).
Hailes, H.C., H. Sandeep, F. Leadlay, I.C. Lennon, S.V. Ley, and J. Staunton: Biosynthesis of Tetronasin, Part 3: Preparation of Deuterium Labelled Tri- and Tetraketides as Putative Biosynthetic Precursor of Tetronasin. Tetrahedron Lett., 35, 315 (1994).
Walser-volken, P.: Ph.D. Thesis. Basel: 1993.
Allinger, N.L., and U. Burkert: Molecular Mechanics (ACS Monograph, 171 ). Washington, DC: American Chemical Society. 1982.
Hesse, G.: In: Methoden der organischen Chemie (Houben-Weyl), Vol. Vl/ld, 4th Ed. ( E. Müller, O. Bayer, p. 224. Stuttgart: Thieme. 1978.
Luckner, M.: Secondary Metabolism in Microorganisms, Plants and Animals, 3rd Ed. Berlin-Heidelberg-New York: Springer. 1990.
Steiner, O., and Ch. Tamm: Synthetic Studies Towards Spirostaphylotrichins: Synthesis of Building Blocks. Tetrahedron Lett., 34, 6729 (1993).
Harada, N., and K. Nakanishi: A Method for Determining the Chirahties of Optically Active Glycols. J. Am. Chem. Soc., 91, 3989 (1969).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag/Wien
About this chapter
Cite this chapter
Walser-Volken, P., Tamm, C. (1996). The Spirostaphylotrichins and Related Microbial Metabolites. In: Herz, W., Kirby, G.W., Moore, R.E., Steglich, W., Tamm, C. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 67. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9406-5_2
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9406-5_2
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-9408-9
Online ISBN: 978-3-7091-9406-5
eBook Packages: Springer Book Archive