Summary
To determine the endocrine, ophthalmologic, and tumor growth control responses after stereotactic radiosurgery using the gamma unit, we reviewed our experience in 35 patients with pituitary adenomas. Twenty-four females and 11 males (mean age 47 years, range 9–81 years) had radiosurgery with average follow-up of 26 months (range 6–60 months). Most patients were refractory to surgical removal.
Fifteen patients had Cushing’s disease. Prior transsphenoidal resection was performed in 14 patients (6 had two prior operations), fractionated radiotherapy in 3, and adrenalectomy in 2. In 11 evaluable patients, the hormone response was normalized in 8, decreased in 2 and increased in 1. Five patients remained on Cortisol suppression. Of 12 patients with imaging follow-up, 4 had decreased tumor size, 6 had no change, and 2 had an increase; these 2 patients underwent subsequent surgery.
Ten patients had acromegaly, and 6 had undergone prior surgery. Of 8 evaluable patients, growth hormone secretion has normalized in 3, decreased in 3, and increased in 2. Six tumors decreased in size, and 2 were unchanged. One patient had repeat resection 21 months after radiosurgery and one patient underwent repeat radiosurgery.
Ten patients had non-secreting adenomas; all 10 had prior operations (1–4 operations, 6 underwent frontal craniotomy) and 5 had undergone fractionated radiotherapy. Eight patients had panhypopituitarism prior to radiosurgery. Four tumors decreased in size and 6 were without change. One patient had worsening of vision and had optic nerve decompression without improvement; 2 had improvement in visual function after radiosurgery. One patient died 16 months later from hypothalamic insufficiency (after 4 prior operations and fractionated radiotherapy).
Radiosurgery is a potentially effective management option for recurrent small pituitary adenomas or for primary management of tumors unsuitable for microsurgery. Radiosurgical dose planning with selective beam blocking and shifting is necessary to preserve visual function. Dose escalation or repeat irradiation may be necessary to improve endocrine control in secreting tumors.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arnott RD, Pestell RG, McKelvie PA, Henderson JK, McNeill PM, Alford FP (1990) A critical evaluation of transsphenoidal pituitary surgery in the treatment of Cushing’s disease: Prediction of outcome. Acta Endocrinol (Copenh) 123: 423–430
Backlund EO, Ganz JC (1993) Pituitary adenomas: Gamma Knife. In: Alexander E, Loeffler JS, Lunsford LD (eds) Stereotactic radiosurgery. McGraw-Hill, New York, 167–173
Bell P, Atkinson AB, Hadden DR, Kennedy L, Leslie H, Merrett D, Sheridan B (1986) Bromocriptine reduces growth hormone in acromegaly. Arch Intern Med 146: 1145–1149
Davis DH, Laws ER, Ilstrup DM, Speed JK, Caruso M, Shaw EG, Abboud CF, Scheithauer BW, Root LM, Schleck C (1993) Results of surgical treatment for growth-hormone secreting pituitary adenomas. J Neurosurg 79: 70–75
Duma CM, Lunsford LD, Kondziolka D, Harsh GR, Flickinger JC (1993) Stereotactic radiosurgery of cavernous sinus meningiomas as an addition or alternative to microsurgery. Neurosurgery 32: 699–705
Flickinger JC (1989) An integrated logistic formula for the prediction of complications from radiosurgery. Int J Radiat Oncol Biol Phys 17: 879–885
Flickinger JC, Nelson DB, Martinez AJ, Deutsch M, Taylor F (1989) Radiotherapy of nonfunctional adenomas of the pituitary gland: results with long-term follow-up. Cancer 63: 2409–2414
Flickinger JC, Lunsford LD, Wu A, Maitz A, Kalend A (1990) Treatment planning for gamma knife radiosurgery with multiple isocenters. Int J Radiat One Biol Phys 18: 1495–1501
Flickinger JC, Maitz A, Kalend A, Lunsford LD, Wu A (1990) Treatment volume shaping with selective beam blocking using the Leksell gamma unit. Int J Radiat Oncol Biol Phys 19: 783–789
Friedman RB, Oldfield EH, Nieman LK, Chrousos GP, Doppman JL, Cutler GF, Loriaux DL (1989) Repeat transsphenoidal surgery for Cushing’s disease. J Neurosurg 71: 520–527
Goffman TE, Dewan R, Arakaki R, Görden P, Oldfield EH, Glatstein E (1992) Persistent or recurrent acromegaly: long-term endocrinologic efficacy and neurologic safety of postsurgical radiation therapy. Cancer 69: 271–275
Howlett TA, Plowman PN, Wass JR, Rees LH, Jones AE, Bessner GM (1989) Megavoltage pituitary irradiation in the management of Cushing’s disease and Nelson’s syndrome: long- term follow-up. Clin Endocrinol 31: 309–323
Kjellberg RN, Klimen B (1979) Lifetime effectiveness - a system of therapy for pituitary adenomas, emphasizing Bragg peak photon hypophysectomy. In: Linfoot JA (ed) Recent advances in the diagnosis and treatment of pituitary tumors. Raven, New York, pp 269–288
Kondziolka D, Lunsford LD, Coffey RJ, Flickinger JC (1991) Stereotactic radiosurgery of meningiomas. J Neurosurg 74: 552–559
Levy RP, Fabrikant JI, Frankel KA (1993) Particle-beam irradiation of the pituitary gland. In: Alexander E, Loeffler JS, Lunsford LD (eds) Stereotactic radiosurgery. McGraw-Hill, New York, pp 157–165
Littley MD, Shalet SM, Beardwell CG, Ahmed SR, Applegate G, Sutton ML (1989) Hypopituitarism following external radiotherapy for pituitary tumors in adults. Q J Med 70: 145–160
Lunsford LD, Flickinger JC, Lidner G, Maitz A (1989) Stereotactic radiosurgery of the brain using the first United States 201 cobalt-60 source gamma knife. Neurosurgery 24: 151–159
McCollough WM, Marcus RB, Rhoton AL, Ballinger WE, Million RR (1991) Long-term follow-up of radiotherapy for pituitary adenoma: the absence of late recurrence after > 4500 Gy. Int J Radiation Oncol Biol Phys 21: 607–614
Moberg E, Trampe E, Wersall J, Werner S (1991) Long-term effects of radiotherapy and bromocriptine treatment in patients with previous surgery for macroprolactinomas. Neurosurgery 29: 200–205
Rahn T (1993) Gamma knife surgery in pituitary adenomas. Presented at the International Stereotactic Radiosurgery Society Meeting, Stockholm, Sweden
Stephanian E, Lunsford LD, Coffey RJ, Bissonette DJ, Flickinger JC (1992) Gamma knife surgery for sellar and suprasellar tumors. Neurosurg Clin North Am 3: 207–218
Thoren M, Rahn T, Guo WY, Werner S (1991) Stereotactic radiosurgery with cobalt-60 gamma unit in the treatment of growth hormone-producing pituitary tumors. Neurosurgery 29: 663–668.
Tindall GT, Herring CJ, Clark RV, Adams DA, Watts NB (1990) Cushings disease: results of transsphenoidal microsurgery with emphasis on surgical failures. J Neurosurg 72: 363–369
Tindall GT, Oyesiku NM, Watts NB, Clark RV, Christy JH, Adams DA (1993) Transsphenoidal adenomectomy for growth hormone-secreting pituitary adenomas in acromegaly: outcome analysis and determinants of failure. J Neurosurg 78: 205–215
Vance ML, Evans WS, Thorner MO (1984) Bromocriptine. Ann Intern Med 100: 78–91
Vance ML, Harris AG (1991) Long-term treatment of 189 acromegalic patients with the somatostatin analog octreotide. Arch Intern Med 151: 1573–1578
Wu A, Lindner G, Maitz A, Kalend AM, Lunsford LD, Flickinger JC, Bloomer WD (1990) Physics of gamma knife approach on converent beams and stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 18: 941–949
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag
About this paper
Cite this paper
Pollock, B.E., Kondziolka, D., Lunsford, L.D., Flickinger, J.C. (1994). Stereotactic Radiosurgery for Pituitary Adenomas: Imaging, Visual and Endocrine Results. In: Lindquist, C., Kondziolka, D., Loeffler, J.S. (eds) Advances in Radiosurgery. Acta Neurochirurgica Supplementum, vol 62. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9371-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9371-6_7
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-9373-0
Online ISBN: 978-3-7091-9371-6
eBook Packages: Springer Book Archive