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The function of the NMDA-receptor during normal brain aging

  • W. E. Müller
  • S. Stoll
  • K. Scheuer
  • A. Meichelböck
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 44)

Summary

Age-related changes of N-methyl-D-aspartate (NMDA) receptors have been found in cortical areas and in the hippocampus of many species. On the basis of a variety of experimental observations it has been suggested that the decrease of NMDA-receptor density might be one of the causative factors of the cognitive decline with aging. Based on these findings several strategies have been developed to improve cognition by compensating the NMDA-receptor deficits in aging. The most promising approaches are the indirect activation of glutamatergic neurotransmission by agonists of the glycine site or the restoration of the age-related deficit of receptor density by several nootropics.

Keywords

NMDA Receptor Membrane Fluidity Passive Avoidance NMDA Antagonist Aged Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • W. E. Müller
    • 1
  • S. Stoll
    • 1
  • K. Scheuer
    • 1
  • A. Meichelböck
    • 1
  1. 1.Department of PsychopharmacologyCentral Institute of Mental HealthMannheimFederal Republic of Germany

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