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Primary cultures of neurons for testing neuroprotective drug effects

  • H. Oberpichler-Schwenk
  • J. Krieglstein
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 44)

Summary

Primary cultures of neurons are widely used for the investigation of pathomechanisms of neuronal damage und for the evaluation of neuroprotective drug effects. The present paper gives a short survey of frequently used primary neuronal culture systems and of experimental measures for the induction of defined neuronal damage with particular respect to the pathomechanisms of cerebral ischemia. Neuroprotective durg effects as achieved under these conditions are reviewed, and the neuroprotective effects of glutamate antagonists, radical scavengers, and neural growth factors are discussed in some more detail.

Keywords

Cerebral Ischemia Neuroprotective Effect Middle Cerebral Artery Occlusion Neuronal Damage Neuronal Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AMPA

α-Amino-3-hydroxy-5-methylisoxazole-4-propionate

APV

2-Amino-5-phosphonovaleric acid

CNQX

6-Cyano-7-nitroquinoxaline-2,3-dione

DNQX

6,7-Dinitroquinoxaline-2,3-dione

LDH

Lactate dehydrogenase

NBQX

2,3-Dihydro-6-nitro-7-sulphamoyl-benzo(f)quinoxaline

NMDA

N-Methyl-D-aspartate

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • H. Oberpichler-Schwenk
    • 1
  • J. Krieglstein
    • 1
  1. 1.Institut für Pharmakologie und ToxikologiePhilipps-UniversitätMarburgFederal Republic of Germany

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