Advertisement

Transgenic mice and the pathogenesis of poliomyelitis

  • V. R. Racaniello
  • R. Ren
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 9)

Summary

Transgenic mice expressing the cell receptor for poliovirus have been generated and are susceptible to poliovirus infection. TgPVR mice have been used to answer questions about the pathogenesis of poliovirus infection. Despite the widespread pattern of PVR expression, poliovirus infection in TgPVR mice is restricted to only a few sites, indicating that poliovirus tropism is not controlled solely by the ability of cells to bind virus. After intramuscular inoculation, poliovirus travels to the spinal cord by axonal transport. This route of entry into the central nervous system may play a role in the pathogenesis of poliovirus infections in humans.

Keywords

Mouse Hepatitis Virus Rickettsial Infection Inactivate Poliovirus Vaccine Intramuscular Inoculation Poliovirus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Koike S, Taya C, Kurata T, Abe S, Ise I, Yonekawa H, Nomoto A (1991) Transgenic mice susceptible to polio virus. Proc Natl Acad Sci USA 88: 951–955PubMedCrossRefGoogle Scholar
  2. 2.
    Ren R, Costantini FC, Gorgacz EJ, Lee JJ, Racaniello VR (1990) Transgenic mice expressing a human poliovirus receptor: A new model for poliomyelitis. Cell 63: 353–362Google Scholar
  3. 3.
    Mendelsohn C, Wimmer E, Racaniello VR (1989) Cellular receptor for poliovirus: molecular cloning, nucleotide sequence and expression of a new member of the immunoglobulin superfamily. Cell 56: 855–865PubMedCrossRefGoogle Scholar
  4. 4.
    Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47: 333–348PubMedCrossRefGoogle Scholar
  5. 5.
    Greve JM, Davis G, Meyer AM, Forte CP, Yost SC, Marlor CW, Kamarck ME, McClelland A (1989) The major human rhinovirus receptor is ICAM-1. Cell 56: 839–847PubMedCrossRefGoogle Scholar
  6. 6.
    Staunton DE, Merluzzi VJ, Rothlein R, Barton R, Marlin SD, Springer TA (1989) A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell 56: 849–853PubMedCrossRefGoogle Scholar
  7. 7.
    Tomassini JE, Graham D, DeWitt CM, Lineberger DW, Rodkey JA, Colonno RJ (1989) cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1. Proc Natl Acad Sci USA 86: 4907–4911Google Scholar
  8. 8.
    Williams RK, Jiang G-S, Holmes KV (1991) Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Proc Natl Acad Sci USA 88: 5533–5536PubMedCrossRefGoogle Scholar
  9. 9.
    Kaplan G, Freistadt MS, Racaniello VR (1990) Neutralization of poliovirus by cell receptors expressed in insect cells. J Virol 64: 4697–4702PubMedGoogle Scholar
  10. 10.
    Kaplan G, Racaniello VR (1991) Down regulation of poliovirus receptor RNA in HeLa cells resistant to poliovirus infection. J Virol 65:1829–1835PubMedGoogle Scholar
  11. 11.
    Evans CA, Byatt PH, Chambers VC, Smith WM (1954) Growth of neurotropic viruses in extraneural tissues VI. Absence of in vivo multiplication of poliomyelitis virus, types I and II, after intratesticular inoculation of monkeys and other animals. J Immunol 72:348–352Google Scholar
  12. 12.
    Brown RH, Johnson D, Ogonowski M, Weiner HL (1987) Type 1 human poliovirus binds to human synaptosomes. Ann Neurol 21: 64–70PubMedCrossRefGoogle Scholar
  13. 13.
    Holland JJ (1961) Receptor affinities as major determinants of enterovirus tissue tropisms in humans. Virology 15: 312–326PubMedCrossRefGoogle Scholar
  14. 14.
    Kunin CM, Jordan WS (1961) In vitro adsorption of poliovirus by noncultured tissues. Effect of species, age and malignancy. Am J Hyg 73: 245–257Google Scholar
  15. 15.
    Crowell RL, Landau BJ (1983) Receptors in the initiation of Picornavirus infections. In: Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology. Academic Press, New York, pp 1–42Google Scholar
  16. 16.
    Ren R, Racaniello V (1992) Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice. J Virol 66: 296–304PubMedGoogle Scholar
  17. 17.
    Freistadt MF, Kaplan G, Racaniello VR (1990) Heterogeneous expression of poliovirus receptor-related proteins in human cells and tissues. Mol Cell Biol 10: 5700–5706PubMedGoogle Scholar
  18. 18.
    Bodian D (1959) Poliomyelitis: pathogenesis and histopathology. In: Rivers TM, Horsfall FL (eds) Viral and rickettsial infections of man. Lippincott, Philadelphia, pp 479–498Google Scholar
  19. 19.
    Morrison LA, Fields BN (1991) Parallel mechanisms in the neuropathogenesis of enteric virus infections. J Virol 65: 2767–2772PubMedGoogle Scholar
  20. 20.
    Sabin AB (1957) Properties of attenuated polioviruses and their behavior in human beings In: Rivers TM (ed) Cellular biology, nucleic acids and viruses. New York Academy of Science, New York, pp 113–133Google Scholar
  21. 21.
    Bodian D, Horstmann DH (1965) Polioviruses. In: Horsfall FL, Tamm I (eds) Viral and rickettsial infections of man. Lippincott, Philadelphia, pp 430–473Google Scholar
  22. 22.
    Melnick JL (1985) Enteroviruses: polioviruses, coxsackieviruses, echoviruses and newer enteroviruses. In: Fields BN, Knipe DM, Chanock RM, Melnick JL, Roizman B, Shope RE (eds) Virology. Raven Press, New York, pp 705–738Google Scholar
  23. 23.
    Nathanson N, Bodian D (1961) Experimental poliomyelitis following intramuscular virus injection. 1. The effect of neural block on a neurotropic and a pantropic strain. Bull Johns Hopkins Hosp 108: 308–319Google Scholar
  24. 24.
    Nathanson N, Langmuir A (1963) The Cutter incident: poliomyelitis following formaldehyde-inactivated poliovirus vaccination in the United States during the spring of 1955. III. Comparison of the clinical character of vaccinated and contact cases occurring after use of high rate lots of Cutter vaccine. Am J Hyg 78: 61–81Google Scholar
  25. 25.
    Ren R, Racaniello VR (1992) Poliovirus spreads from muscle to the central nervous system by neural pathways. J Infect Dis 166: 635–654CrossRefGoogle Scholar
  26. 26.
    Bodian D (1955) Emerging concept of poliomyelitis infection. Science 12: 105–108CrossRefGoogle Scholar
  27. 27.
    Sabin AB (1956) Pathogenesis of Poliomyelitis: reappraisal in light of new data. Science 123: 1151–1157PubMedCrossRefGoogle Scholar
  28. 28.
    Morrison LA, Sidman RL, Fields BN (1991) Direct spread of reovirus from the intestinal lumen to the central nervous system through vagal autonomic nerve fibers. Proc Natl Acad Sci USA 88: 3852–3856PubMedCrossRefGoogle Scholar
  29. 29.
    Flamand A, Gagner J, Morrison LA, Fields BN (1991) Penetration of the nervous systems of suckling mice by mammalian reoviruses. J Virol 65: 123–131PubMedGoogle Scholar
  30. 30.
    Tyler KL, McPhee DA, Fields BN (1986) Distinct pathways of viral spread in the host determined by reovirus SI gene segment. Science 233: 770–774PubMedCrossRefGoogle Scholar
  31. 31.
    Tyler KL, Virgin IVth HW, Bassel-Duby R, Fields BN (1989) Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system. J Exp Med 170: 887 - 900PubMedCrossRefGoogle Scholar
  32. 32.
    Levine B, Hardwick JM, Trapp BD, Crawford TO, Bollinger RC, Griffin DE (1991) Antibody-mediated clearance of alphavirus infection from neurons. Science 254: 856–859PubMedCrossRefGoogle Scholar
  33. 33.
    Morrison ME, Racaniello VR (1992) Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene. J Virol 66: 2807–2813PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • V. R. Racaniello
    • 1
  • R. Ren
    • 1
  1. 1.Department of MicrobiologyColumbia University College of Physicians and SurgeonsNew YorkUSA

Personalised recommendations