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Host-cell receptors for Sindbis virus

  • Conference paper
Positive-Strand RNA Viruses

Part of the book series: Archives of Virology Supplementum ((ARCHIVES SUPPL,volume 9))

Summary

Sindbis virus has a very wide host range, infecting many species of mosquitoes and other hematophagous insects and infecting many species of higher vertebrates. We have used two approaches to study host cell receptors used by Sindbis virus to enter cells. Antiidiotype antibodies to neutralizing antibodies directed against glycoprotein E2 of the virus identified a 63-kDa protein as a putative receptor in chicken cells. In a second approach, monoclonal antibodies identified a 67 kDa protein, believed to be a high affinity laminin receptor, as a putative receptor in mammalian cells and in mosquito cells. We conclude that the virus attains its very wide host range by two mechanisms. In one mechanism, the virus is able to use more than one protein as a receptor. In a second mechanism, the virus utilizes proteins as receptors that are highly conserved across the animal kingdom.

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Author information

Author notes

  1. K.-S. Wang

    Present address: Chiron Corporation, Emeryville, California, USA

  2. A. L. Schmaljohn

    Present address: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA

  3. R. J. Kuhn

    Present address: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA

Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, CA, 91125, USA

    Dr. J. H. Strauss, K.-S. Wang, R. J. Kuhn & E. G. Strauss

  2. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

    A. L. Schmaljohn

Authors
  1. Dr. J. H. Strauss
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  2. K.-S. Wang
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  3. A. L. Schmaljohn
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  4. R. J. Kuhn
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  5. E. G. Strauss
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Editor information

Editors and Affiliations

  1. Department of Biology, Georgia State University, Atlanta, Georgia, USA

    Margo A. Brinton

  2. Arthropod-borne and Infectious Disease Laboratory (AIDL), Colorado State University, Fort Collins, Colorado, USA

    Charles H. Calisher

  3. Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin, USA

    Roland Rueckert

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© 1994 Springer-Verlag

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Strauss, J.H., Wang, KS., Schmaljohn, A.L., Kuhn, R.J., Strauss, E.G. (1994). Host-cell receptors for Sindbis virus. In: Brinton, M.A., Calisher, C.H., Rueckert, R. (eds) Positive-Strand RNA Viruses. Archives of Virology Supplementum, vol 9. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9326-6_46

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  • DOI: https://doi.org/10.1007/978-3-7091-9326-6_46

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82522-8

  • Online ISBN: 978-3-7091-9326-6

  • eBook Packages: Springer Book Archive

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