Host-cell receptors for Sindbis virus

  • J. H. Strauss
  • K.-S. Wang
  • A. L. Schmaljohn
  • R. J. Kuhn
  • E. G. Strauss
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 9)


Sindbis virus has a very wide host range, infecting many species of mosquitoes and other hematophagous insects and infecting many species of higher vertebrates. We have used two approaches to study host cell receptors used by Sindbis virus to enter cells. Antiidiotype antibodies to neutralizing antibodies directed against glycoprotein E2 of the virus identified a 63-kDa protein as a putative receptor in chicken cells. In a second approach, monoclonal antibodies identified a 67 kDa protein, believed to be a high affinity laminin receptor, as a putative receptor in mammalian cells and in mosquito cells. We conclude that the virus attains its very wide host range by two mechanisms. In one mechanism, the virus is able to use more than one protein as a receptor. In a second mechanism, the virus utilizes proteins as receptors that are highly conserved across the animal kingdom.


Wide Host Range Chicken Embryo Fibroblast Sindbis Virus Mosquito Cell Laminin Receptor 
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • J. H. Strauss
    • 1
  • K.-S. Wang
    • 1
  • A. L. Schmaljohn
    • 2
  • R. J. Kuhn
    • 1
  • E. G. Strauss
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of Maryland School of MedicineBaltimoreUSA

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