Recognition of cellular receptors by bovine coronavirus

  • B. Schultze
  • G. Herrler
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 9)


Bovine coronavirus (BCV) initiates infection by attachment to cell surface receptors the crucial component of which is N-acetyl-9-O- acetylneuraminic acid. Inactivation of receptors by neuraminidase treatment and restoration of receptors by enzymatic resialylation of asialo-cells is described as a method to determine (i) the type of sialic acid that is recognized; (ii) the linkage specificity of the viral binding activity; (iii) the minimal amount of sialic acid required for virus attachment. Evidence is presented that both glycoproteins and glycolipids can serve as receptors for BCV provided they contain 9-O-acetylated sialic acid. A model is introduced proposing that after initial binding to sialic acid-containing receptors, the S-protein of BCV interacts with a specific protein receptor. This interaction may result in a conformational change that exposes a fusogenic domain and thus induces the fusion between the viral and the cellular membrane.


Sialic Acid Infectious Bronchitis Virus Linkage Type Mouse Hepatitis Virus Human Coronavirus 
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • B. Schultze
    • 1
  • G. Herrler
    • 1
  1. 1.Institut für VirologiePhilipps-UniversitätMarburgFederal Republic of Germany

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