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Recombination between Sindbis virus RNAs

  • S. Schlesinger
  • B. G. Weiss
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 9)

Summary

The Sindbis virus RNA genome is divided into two modules - one coding for the nonstructural protein genes and the other coding for the structural protein genes. In our studies of recombination, the two parental RNAs were defective in different modules. Analysis of the recombinant RNAs demonstrated that the parental RNAs each contributed its intact module and that the crossovers occurred within the defective modules. The recombinational events giving rise to infectious virion RNAs could create deletions, rearrangements or insertions as long as they occurred outside of the functional module. These crossovers produced RNA genomes that contained two functional subgenomic RNA promoters.

Keywords

Semliki Forest Virus Sindbis Virus Barley Stripe Mosaic Virus Eastern Equine Encephalitis Virus Brome Mosaic Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • S. Schlesinger
    • 1
  • B. G. Weiss
    • 1
  1. 1.Department of Molecular MicrobiologyWashington University Medical SchoolSt. LouisUSA

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