Histaminase activity of mesenteric artery of the rat
In rat mesenteric artery homogenates histamine is oxidatively deaminated at high rate whereas putrescine is a poor substrate. The oxidation of histamine appears to be mainly catalyzed by an SSAO enzyme with high affinity for benzylamine (Bz.SSAO). Histamine oxidation is inhibited by B24 (2,5-diethoxy-4-aminomethylpyridine), a selective inhibitor of Bz.SSAO enzymes, and reduced by the presence of benzylamine.
KeywordsMesenteric Artery Amine Oxidase Diamine Oxidase Oxidative Deamination Epididymal White Adipose Tissue
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