Skip to main content
SpringerLink
Log in

Properties of mammalian tissue-bound semicarbazide-sensitive amine oxidase: possible clues to its physiological function?

  • Conference paper
Amine Oxidases: Function and Dysfunction

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 41))

  • 176 Accesses

Summary

Semicarbazide-sensitive amine oxidase (SSAO), occurs not only in vascular smooth muscle but also in other cell types (e.g. adipocytes, chondrocytes, odontoblasts), probably in the plasma membrane. Although certain aromatic biogenic amines (e.g. tryptamine, tyramine, ß-phenyl-ethylamine) may be endogenous substrates for SSAO in species such as the rat, the weak activity of SSAO in human tissues towards these amines makes this less likely in man. However SSAO in human and rat vascular homogenates readily converts the aliphatic biogenic amines methylamine and aminoacetone to formaldehyde and methylglyoxal, respectively. Also the xenobiotic aliphatic amine allylamine produces cardiovascular damage in experimental animals by a mechanism which involves its deamination by SSAO to acrolein. Further metabolism of these toxic aliphatic aldehydes may involve glutathione-dependent pathways. Thus, SSAO may be involved not only in the removal of physiologically-active endogenous/xenobiotic amines, but resulting metabolite (aldehyde/H2O2?) formation could also influence cellular function.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andrée TH, Clarke DE (1982) Characteristics of rat skull benzylamine oxidase. Proc Soc Exp Biol Med 171: 298–305.

    PubMed  Google Scholar 

  • Barrand MA, Callingham BA (1982) Monoamine oxidase activities in brown adipose tissues of the rat: some properties and subcellular distribution. Biochem Pharmacol 31: 2177–2184.

    Article  PubMed  CAS  Google Scholar 

  • Barrand MA, Callingham BA, Fox SA (1984) Amine oxidase activities in brown adipose tissue of the rat: identification of semicarbazide-sensitive (clorgyline-resistant activity) at the fat cell membrane. J Pharm Pharmacol 36: 652–658.

    Article  PubMed  CAS  Google Scholar 

  • Blaschko H (1974) The natural history of amine oxidases. Rev Physiol Biochem Pharmacol 70: 83–148.

    Article  PubMed  CAS  Google Scholar 

  • Blicharski JRD, Lyles GA (1990) Semicarbazide-sensitive amine oxidase activity in rat aortic cultured smooth muscle cells. J Neural Transm [Suppl] 32: 337–339.

    CAS  Google Scholar 

  • Blicharski JRD, Lyles GA (1991) D,L-buthionine sulphoximine, a glutathione-depleting agent, potentiates allylamine-induced cytotoxicity in rat aortic smooth muscle cell cultures. Br J Pharmacol 102: 184P.

    Google Scholar 

  • Boor PJ, Hysmith RM (1987) Allylamine cardiovascular toxicity. Toxicology 44: 129–145.

    Article  PubMed  CAS  Google Scholar 

  • Boor PJ, Hysmith RM, Sanduja R (1990) A role for a new vascular enzyme in the metabolism of xenobiotic amines. Circ Res 66: 249–252.

    PubMed  CAS  Google Scholar 

  • Boor PJ, Sanduja R, Nelson TJ, Ansari GAS (1987) In vivo metabolism of the cardiovascular toxin, allylamine. Biochem Pharmacol 36: 4347–4353.

    Article  PubMed  CAS  Google Scholar 

  • Callingham BA, Holt A, Elliott J (1991) Properties and functions of the semicarbazide-sensitive amine oxidases. Biochem Soc Trans 19: 228–233.

    PubMed  CAS  Google Scholar 

  • Clarke DE, Lyles GA, Callingham BA (1982) A comparison of cardiac and vascular clorgyline-resistant amine oxidase and monoamine oxidase. Biochem Pharmacol 31: 27–35.

    Article  PubMed  CAS  Google Scholar 

  • Coquil JF, Goridis C, Mack G, Neff NH (1973) Monoamine oxidase in rat arteries: evidence for different forms and selective localization. Br J Pharmacol 48: 590–599.

    PubMed  CAS  Google Scholar 

  • DeLeve LD, Kaplowitz N (1991) Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 52: 287–305.

    Article  PubMed  CAS  Google Scholar 

  • Dostert P, Guffroy C, Strolin Benedetti M, Boucher T (1984) Inhibition of semicarbazide-sensitive amine oxidase by monoamine oxidase B inhibitors from the oxazolidinone series. J Pharm Pharmacol 36: 782–785.

    Article  PubMed  CAS  Google Scholar 

  • Elliott J, Callingham BA, Sharman DF (1989a) Semicarbazide-sensitive amine oxidase (SSAO) of the rat aorta. Interactions with some naturally occurring amines and their structural analogues. Biochem Pharmacol 38: 1507–1515.

    Article  PubMed  CAS  Google Scholar 

  • Elliott J, Callingham BA, Sharman DF (1989b) Metabolism of amines in the isolated perfused mesenteric arterial bed of the rat. Br J Pharmacol 98: 507–514.

    PubMed  CAS  Google Scholar 

  • Elliott J, Callingham BA, Sharman DF (1989c) The influence of amine metabolizing enzymes on the pharmacology of tyramine in the isolated perfused mesenteric arterial bed of the rat. Br J Pharmacol 98: 515–522.

    PubMed  CAS  Google Scholar 

  • Ferkany JW, Andrée TH, Clarke DE, Enna SJ (1981) Neurochemical effects of kojic amine, and its interaction with benzylamine oxidase. Neuropharmacology 20: 1177–1182.

    Article  PubMed  CAS  Google Scholar 

  • Fernandez de Arriba A, Balsa D, Tipton KF, Unzeta M (1990) Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in bovine eye. J Neural Transm [Suppl] 32: 327–330.

    CAS  Google Scholar 

  • Guffroy C, Boucher T, Strolin Benedetti M (1985) Further investigations of the metabolism of two trace amines, β-phenylethylamine and p-tyramine by rat aorta semicarbazide-sensitive amine oxidase. In: Boulton AA, Maitre L, Bieck PR, Riederer P (eds) Neuropharmacology of the trace amines. Humana Press, Clifton NJ, pp 39–50.

    Chapter  Google Scholar 

  • Hayes BE, Ostrow PT, Clarke DE (1983) Benzylamine oxidase in normal and atherosclerotic aortae. Exp Mol Pathol 38: 243–254.

    Article  PubMed  CAS  Google Scholar 

  • Heck Hd’A, Casanova M, Starr TB (1990) Formaldehyde toxicity — new understanding. Crit Rev Toxicol 20: 397–426.

    Article  PubMed  CAS  Google Scholar 

  • Hysmith RM, Boor PJ (1987) In vitro expression of benzylamine oxidase activity in cultured porcine smooth muscle cells. J Cardiovasc Pharmacol 9: 668–674.

    Article  PubMed  CAS  Google Scholar 

  • Hysmith RM, Boor PJ (1988) Role of benzylamine oxidase in the cytotoxicity of allylamine toward aortic smooth muscle cells. Toxicology 51: 133–145.

    Article  PubMed  CAS  Google Scholar 

  • Janes SM, Mu D, Wemmer D, Smith AJ, Kaur S, Maltby D, Burlingame AL, Klinman JP (1990) A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase. Science 248: 981–987.

    Article  PubMed  CAS  Google Scholar 

  • Lewinsohn R (1984) Mammalian monoamine-oxidizing enzymes, with special reference to benzylamine oxidase in human tissues. Brazilian J Med Biol Res 17: 223–256.

    CAS  Google Scholar 

  • Lizcano JM, Balsa D, Tipton KF, Unzeta M (1990) Amine oxidase activities in bovine lung. J Neural Transm [Suppl] 32: 341–344.

    CAS  Google Scholar 

  • Lizcano JM, Balsa D, Tipton KF, Unzeta M (1991) The oxidation of dopamine by the semicarbazide-sensitive amine oxidase (SSAO) from rat vas deferens. Biochem Pharmacol 41: 1107–1110.

    Article  PubMed  CAS  Google Scholar 

  • Lyles GA (1984) The interaction of semicarbazide-sensitive amine oxidase with MAO inhibitors. In: Tipton KF, Dostert P, Strolin Benedetti M (eds) Monoamine oxidase and disease. Academic Press, London, pp 547–556.

    Google Scholar 

  • Lyles GA, Archer DR (1986) Monoamine oxidase activity in dissociated cell fractions from rat skeletal muscle. J Pharm Pharmacol 38: 288–293.

    Article  PubMed  CAS  Google Scholar 

  • Lyles GA, Bertie KH (1987) Properties of a semicarbazide-sensitive amine oxidase in rat articular cartilage. Pharmacol Toxicol 60 [Suppl] 1: 33.

    Google Scholar 

  • Lyles GA, Chalmers J (1992) The metabolism of aminoacetone to methylglyoxal by semicarbazide-sensitive amine oxidase in human umbilical artery. Biochem Pharmacol 43: 1409–1414.

    Article  PubMed  CAS  Google Scholar 

  • Lyles GA, Holt A, Marshall CMS (1990) Further studies on the metabolism of meth-ylamine by semicarbazide-sensitive amine oxidase activities in human plasma, umbilical artery and rat aorta. J Pharm Pharmacol 42: 332–338.

    Article  PubMed  CAS  Google Scholar 

  • Lyles GA, Marshall CMS, McDonald IA, Bey P, Palfreyman MG (1987) Inhibition of rat aorta semicarbazide-sensitive amine oxidase by 2-phenyl-3-haloallylamines and related compounds. Biochem Pharmacol 36: 2847–2853.

    Article  PubMed  CAS  Google Scholar 

  • Lyles GA, McDougall SA (1989) The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities. J Pharm Pharmacol 41: 97–100.

    Article  PubMed  CAS  Google Scholar 

  • Lyles GA, Singh I (1985) Vascular smooth muscle cells: a major source of the semicarbazide-sensitive amine oxidase of the rat aorta. J Pharm Pharmacol 37: 637–643.

    Article  PubMed  CAS  Google Scholar 

  • Lyles GA, Taneja DT (1987) Effects of amine oxidase inhibitors upon tryptamine metabolism and tryptamine-induced contractions of rat aorta. Br J Pharmacol 90: 16P.

    Google Scholar 

  • Norqvist A, Fowler CJ, Oreland L (1981) The deamination of monoamines by pig dental pulp. Biochem Pharmacol 30: 403–409.

    Article  PubMed  CAS  Google Scholar 

  • Norqvist A, Oreland L (1989) Localization of a semicarbazide-sensitive serotonin-oxidizing enzyme from porcine dental pulp. Biogenic Amines 6: 65–74.

    CAS  Google Scholar 

  • Precious E, Lyles GA (1988) Properties of a semicarbazide-sensitive amine oxidase in human umbilical artery. J Pharm Pharmacol 40: 627–633.

    Article  PubMed  CAS  Google Scholar 

  • Precious E, Gunn CE, Lyles GA (1988) Deamination of methylamine by semicarbazide-sensitive amine oxidase in human umbilical artery and rat aorta. Biochem Pharmacol 37: 707–713.

    Article  PubMed  CAS  Google Scholar 

  • Raimondi L, Pirisino R, Ignesti G, Capecchi S, Banchelli G, Buffoni F (1991) Semicarbazide-sensitive amine oxidase activity (SSAO) of rat epididymal white adipose tissue. Biochem Pharmacol 41: 467–470.

    Article  PubMed  CAS  Google Scholar 

  • Ramos K, Grossman SL, Cox LR (1988) Allylamine-induced vascular toxicity in vitro: prevention by semicarbazide-sensitive amine oxidase inhibitors. Toxicol Appl Pharmacol 95: 61–71.

    Article  PubMed  CAS  Google Scholar 

  • Roth JA, Gillis CN (1975) Multiple forms of amine oxidase in perfused rabbit lung. J Pharmacol Exp Ther 194: 537–544.

    PubMed  CAS  Google Scholar 

  • Rucker RB, Goettlich-Riemann W (1972) Properties of rabbit aorta amine oxidases. Proc Soc Exp Biol Med 139: 286–289.

    PubMed  CAS  Google Scholar 

  • Rucker RB, O’Dell BL (1971) Connective tissue amine oxidase. I. Purification of bovine aorta amine oxidase and its comparison with plasma amine oxidase. Biochim Biophys Acta 235: 32–43.

    PubMed  CAS  Google Scholar 

  • Strolin Benedetti M, Dosiert P (1985) Stereochemical aspects of MAO interactions: reversible and selective inhibitors of monoamine oxidase. TIPS 6: 246–251.

    Google Scholar 

  • Suzuki O, Matsumoto T (1984) Some properties of benzylamine oxidase in human aorta. Biogenic Amines 1: 249–257.

    CAS  Google Scholar 

  • Taneja DT, Lyles GA (1988) Use of an oil immersion technique to study the role of amine oxidase inhibition in potentiating tryptamine-induced contractions of rat aorta. Pharmacol Res Commun 20 [Suppl] 4: 127–128.

    Article  Google Scholar 

  • Thornalley PJ (1990) The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life. Biochem J 269: 1–11.

    PubMed  CAS  Google Scholar 

  • Trevethick MA, Olverman HJ, Pearson JD, Gordon JL, Lyles GA, Callingham BA (1981) Monoamine oxidase activities of porcine vascular endothelial and smooth muscle cells. Biochem Pharmacol 30: 2209–2216.

    Article  PubMed  CAS  Google Scholar 

  • Wibo M, Duong AT, Godfraind T (1980) Subcellular location of semicarbazide-sensitive amine oxidase in rat aorta. Eur J Biochem 112: 87–94.

    Article  PubMed  CAS  Google Scholar 

  • Yu PH (1988) Three types of stereospecificity and the kinetic deuterium isotope effect in the oxidative deamination of dopamine as catalyzed by different amine oxidases. Biochem Cell Biol 66: 853–861.

    Article  PubMed  CAS  Google Scholar 

  • Yu PH (1990) Oxidative deamination of aliphatic amines by rat aorta semicarbazide-sensitive amine oxidase. J Pharm Pharmacol 42: 882–884.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK

    Dr. G. A. Lyles

Authors
  1. Dr. G. A. Lyles
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Biochemistry Department, Trinity College, Dublin, Ireland

    K. F. Tipton

  2. Department of Pharmacology, Technion, Haifa, Israel

    M. B. H. Youdim

  3. School of Pharmacy and Biomedicai Sciences, University of Portsmouth, UK

    C. J. Barwell

  4. Department of Pharmacology, University of Cambridge, UK

    B. A. Callingham

  5. Department of Pharmacology and Clinical Pharmacology, University of Dundee, UK

    G. A. Lyles

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag

About this paper

Cite this paper

Lyles, G.A. (1994). Properties of mammalian tissue-bound semicarbazide-sensitive amine oxidase: possible clues to its physiological function?. In: Tipton, K.F., Youdim, M.B.H., Barwell, C.J., Callingham, B.A., Lyles, G.A. (eds) Amine Oxidases: Function and Dysfunction. Journal of Neural Transmission, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9324-2_52

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9324-2_52

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82521-1

  • Online ISBN: 978-3-7091-9324-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation