Advertisement

Chronic effect of the irreversible and reversible selective MAO-A inhibitors on rat pineal melatonin biosynthesis

  • G. F. Oxenkrug
  • P. J. Requintina
  • I. M. McIntyre
  • K. White
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

Acute administration of the irreversible MAO-A inhibitor, clorgyline (2.0 mg/kg, s.c.) and the reversible MAO-A inhibitor, moclobe-mide (10 mg/kg, s.c), increased rat pineal melatonin and related indoles content (HPLC-fluorimetric method). Chronic (21 days) administration of clorgyline attenuated the acute effect of clorgyline on pineal melatonin biosynthesis. The acute effect of moclobemide on melatonin biosynthesis was not affected by chronic moclobemide administration. The observed difference in the chronic effects of irreversible and reversible selective MAO-A inhibitors on melatonin biosynthesis could have clinical implications.

Keywords

Chronic Effect Monoamine Oxidase Inhibitor Melatonin Production Pineal Melatonin Mammalian Pineal Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cesura A, Pletcher A (1992) The new generation of monoamine oxidase inhibitors. Prog Drug Res 38: 171–297.PubMedGoogle Scholar
  2. Da Prada M, Kettler R, Keller HH, Burkard W, Muggli-Maniglio D, Haefely WE (1989) Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. J Pharmacol Exp Ther 248: 400–414.PubMedGoogle Scholar
  3. Finberg JPM (1987) Antidepressant drugs and down-regulation of presynaptic receptors. Biochem Pharmacol 36: 3357–3562.CrossRefGoogle Scholar
  4. Golden RN, Markey SP, Risby ED, Rudorfer MV, Cowdry RW, Potter WZ (1988) Antidepressants reduce whole-body norepinephrine turnover while enhancing 6-hydroxymelatonin output. Arch Gen Psychiatry 45: 150–154.PubMedCrossRefGoogle Scholar
  5. Murphy DL, Tamarkin L, Sunderland T, Garrick NA, Cohen R (1986) Human plasma melatonin is elevated during treatment with the monoamine oxidase inhibitors clorgyline and tranylcypromine but not deprenyl. Psychiatry Res 17: 119–127.PubMedCrossRefGoogle Scholar
  6. Oxenkrug GF (1991) The acute effect of monoamine oxidase inhibitors on serotonin conversion to melatonin. In: Sandier M, Coppen A, Harnett S (eds) 5-Hydroxy-tryptamine in psychiatry. A spectrum of ideas. Oxford University Press, New York, pp 98–109.Google Scholar
  7. Oxenkrug G, McCauley R, McIntyre I, Filipowicz C (1984) Effect of clorgyline and deprenyl on rat pineal melatonin. J Pharm Pharmacol 36: 55W.Google Scholar
  8. Pangerl B, Pangerl A, Reiter RJ (1990) Circadian variations of adrenergic receptors in the mammalian pineal gland: a review. J Neural Transm [Gen Sect] 81: 17–30.CrossRefGoogle Scholar
  9. Vetulani J, Sulser F (1975) Action of various antidepressant treatments reduced reactivity of noradrenergic cyclic AMP generating system in limbic forebrain. Nature 257: 495–496.PubMedCrossRefGoogle Scholar
  10. Wehr TA, Wirz-Justice A (1982) Circadian rhythm mechanisms in affective illness and in antidepressant drug action. Pharmacopsychiatry 15: 31–39.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • G. F. Oxenkrug
    • 1
  • P. J. Requintina
    • 1
  • I. M. McIntyre
    • 2
  • K. White
    • 1
  1. 1.Pineal Research Laboratory, Psychiatry Service, VAMC, and Department of Psychiatry and Human BehaviorBrown University School of Medicine, Psychiatry Service, VAMCProvidenceUSA
  2. 2.Victorian Institute of Forensic PathologyCoronial Services Centre of VictoriaSouth MelbourneAustralia

Personalised recommendations