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The acute effect of the bioprecursor of the selective brain MAO-A inhibitor, MDL 72392, on rat pineal melatonin biosynthesis

  • G. F. Oxenkrug
  • P. J. Requintina
  • A. Yuwiler
  • M. G. Palfreyman
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

The bioprecursor amino acid MDL 72394 is decarboxylated by aromatic L-amino acid decarboxylase (AADC) to liberate MDL 72392, an irreversible selective MAO-A inhibitor. Pretreatment with the AADC inhibitor carbidopa, which does not penetrate the brain-blood barrier, prevents the liberation of the MAO-A inhibitor outside the brain and results in exclusive inhibition of brain MAO-A. We found that systemic administration of MDL 72394 (0.5 mg/kg, i.p.) stimulated rat pineal melatonin biosynthesis. Carbidopa, in a dose-dependent manner, attenuated or completely prevanted MDL-induced stimulation of melatonin biosynthesis in the pineal gland located outside the blood-brain-barrier.

Keywords

Systemic Administration Monoamine Oxidase Pineal Gland Melatonin Level Pineal Melatonin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Oxenkrug GF (1991) The acute effect of monoamine oxidase inhibitors on serotonin conversion to melatonin. In: Coppen X, Sandier M, Harnett S (eds) 5-Hydroxy-tryptamine and mental illness. Oxford University Press, New York, pp 99–108.Google Scholar
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • G. F. Oxenkrug
    • 1
  • P. J. Requintina
    • 1
  • A. Yuwiler
    • 2
  • M. G. Palfreyman
    • 3
  1. 1.Pineal Research Laboratory, Psychiatry Service, VAMC, and Department of Psychiatry and Human BehaviorBrown University (GFO, PJR), Psychiatry Service, VAMCProvidenceUSA
  2. 2.Neurochemistry Laboratory, West Los Angeles Brentwood VAMC, and Department of Psychiatry and Biobehavioral SciencesUCLALos AngelesUSA
  3. 3.Merrell Dow Research InstituteCincinnatiUSA

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