Pharmacodynamics of MDL 72974A: absence of effect on the pressor response to oral tyramine

  • C. Hinze
  • M. Kaschube
  • J. Hardenberg
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)


MDL 72974A, a new irreversible selective inhibitor of monoa-mine oxidase (MAO)-B which is not metabolized to amphetamine-like compounds, is currently being developed for the treatment of Parkinson’s disease. In this double blind, placebo controlled randomized study 24 healthy volunteers (n = 6/dose) received single oral doses of placebo, 1, 12 or 24 mg of MDL 72974A qd over two weeks. Sensitivity to orally administered tyramine was determined under fasting conditions before and after drug administration and the doses of tyramine yielding a 30 mmHg increase of SBP (PD30) compared. The 2-fold increase of tyramine sensitivity at end of treatment seen at all MDL 72974A dose levels, however, is within the variability range of the tyramine pressor response. MDL 72974A selectively inhibits MAO-B at doses up to 24 mg orally and has a favourable safety profile.


mmHg Increase Oral Tyramine Tyramine Pressor Tyramine Sensitivity Irreversible Selective Inhibitor 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • C. Hinze
    • 1
  • M. Kaschube
    • 1
  • J. Hardenberg
    • 2
  1. 1.Marion Merrell DowClinical Pharmacology UnitKehlFederal Republic of Germany
  2. 2.Department of Clinical ResearchStrasbourgFrance

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