The effects of brofaromine, a reversible MAO-A inhibitor, on extracellular serotonin in the raphe nuclei and frontal cortex of freely moving rats

  • P. Celada
  • N. Bel
  • F. Artigas
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)


The effects of brofaromine, a reversible inhibitor of MAO-A, on the extracellular content of serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) have been studied in two regions of the rat brain (midbrain raphe nuclei and frontal cortex). In both areas, locally infused brofaromine induced dose-dependent increases of 5-HT which were more marked in the raphe nuclei. Brofaromine increased extracellular 5-HT more markedly than clorgyline, suggesting that other factors (i.e. inhibition of 5-HT uptake) may be involved in its local effects. Systemic (3 mg/kg, s.c.) brofaromine did not modify extracellular 5-HT in any brain area examined. In contrast, the concurrent administration of brofaromine and deprenyl led to significant changes in the concentration of 5-HT and 5-HIAA in the brain extracellular space. The results are discussed in relation to the role of MAO-A in the control of 5-HT output.


Frontal Cortex Raphe Nucleus Serotoninergic Neurone Extracellular Serotonin Extracellular Content 
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • P. Celada
    • 1
  • N. Bel
    • 1
  • F. Artigas
    • 1
  1. 1.Department of NeurochemistryC.I.D., C.S.I.C.BarcelonaSpain

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