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Chronopharmacological study of moclobemide effect on the rat pineal melatonin biosynthesis

  • G. Oxenkrug
  • P. J. Requintina
  • K. White
  • A. Yuwiler
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

The chronopharmacological hypothesis of the mechanism of the antidepressant effect of MAO-A inhibitors predicts that clinical efficacy depends upon the time of the day at which the drugs are administered. In the present study moclobemide (10 mg/kg, s.c.) injected at the end of the light phase advanced the onset of the nighttime increase of the rat pineal melatonin biosynthesis while the same dose of drug injected at the end of the dark phase delayed the daytime decrease of melatonin biosynthesis. The results obtained suggest that the timing of MAO-A inhibitor administration should be considered in clinical practice.

Keywords

Circadian Rhythm Dark Phase Pineal Melatonin Melatonin Biosynthesis Pineal Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • G. Oxenkrug
    • 1
  • P. J. Requintina
    • 1
  • K. White
    • 1
  • A. Yuwiler
    • 2
  1. 1.Pineal Research Laboratory, Psychiatry Service, VAMC, and Department of Psychiatry and Human BehaviorBrown University School of Medicine, Psychiatry Service, VAMCProvidenceUSA
  2. 2.Neurochemistry Laboratory, West Los Angeles Brentwood VAMC, and Department of Psychiatry and Biobehavioral SciencesUCLALos AngelesUSA

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