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Food-derived hetero-cyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism

  • W. Maruyama
  • A. Ota
  • A. Takahashi
  • T. Nagatsu
  • M. Naoi
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

The effects of heterocyclic amines, pyrolysis products of tryp-tophan, on monoamine metabolism were examined. Among these amines, 3-amino-1, 4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) are potent inhibitors of the enzymes related to amine metabolism. They inhibited type A monoamine oxidase more markedly than type B. After culture of a dopamine cell model, clonal pheochromocytoma PC12h cells, with Trp-P-1 activity of tyrosine hydroxylase was decreased by reduction of its affinity to the biopterin cofactor. Trp-P-1 and Trp-P-2 inhibited tryptophan hydroxylase competitively with the substrate and non-competitively with biopterin. These results suggest that food-derived heterocyclic amines may perturb the monoamine levels in the brain through the inhibition of the biosynthesis and metabolism of biogenic amines.

Keywords

Tyrosine Hydroxylase Biogenic Amine Tryptophan Hydroxylase Heterocyclic Amine Oxygen Oxidoreductase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • W. Maruyama
    • 1
  • A. Ota
    • 2
  • A. Takahashi
    • 1
  • T. Nagatsu
    • 3
  • M. Naoi
    • 4
  1. 1.Department of NeurologyNagoya University School of MedicineNagoyaJapan
  2. 2.First Department of PhysiologySchool of MedicineJapan
  3. 3.Division of Molecular Genetics (II) Neurochemistry, Institute for Comprehensive Medical ScienceFujita Health UniversityToyoakeJapan
  4. 4.Department of BiosciencesNagoya Institute of TechnologyGokiso-cho, Showa-ku, 466 NagoyaJapan

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