Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues
Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro 16-6491 was replaced by an ester bond an increase in potency of the order of 150–200 times was obtained.
KeywordsAmide Bond Platelet Membrane Carboxylic Ester Association Rate Constant Monoamine Oxidase Type
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