Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues

  • E. L. Mullan
  • C. H. Williams
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)


Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro 16-6491 was replaced by an ester bond an increase in potency of the order of 150–200 times was obtained.


Amide Bond Platelet Membrane Carboxylic Ester Association Rate Constant Monoamine Oxidase Type 
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • E. L. Mullan
    • 1
  • C. H. Williams
    • 1
  1. 1.Division of BiochemistryQueen’s UniversityBelfastUK

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