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Interactions between substituted tryptamine analogues, MAO inhibitors and cytochrome P-450

  • M. Costanzo
  • M. Valoti
  • V. Perez
  • M. Unzeta
  • G. P. Sgaragli
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

The effects of some MAO inhibitors, N-acetylenic analogues of tryptamine, on rat liver microsomal cytochrome P-450 (cyt P-450) have been investigated. All the compounds tested interacted with cyt P-450 with Ks values ranging between 14 and 358 μM (clorgyline Ks = 10.5 μM). Compounds with a tertiary amine and those possessing a secondary amine group in the acetylenic side chain exhibited type I and type II difference spectra, respectively. Aniline hydroxylase activity was inhibited irreversibly and in a time-dependent fashion by all compounds tested with IC50 ranging between 7 x 10-5 and 7 x 10-3 M (clorgyline 10-4 M).

Keywords

Tertiary Amine Difference Spectrum Secondary Amine Group NADPH Generate System Aniline Hydroxylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • M. Costanzo
    • 1
  • M. Valoti
    • 2
  • V. Perez
    • 1
  • M. Unzeta
    • 1
  • G. P. Sgaragli
    • 2
  1. 1.Department de Bioquimica i Biologia MolecularUniversidad Autonoma de BarcelonaSpain
  2. 2.Istituto di Scienze FarmacologicheUniversità di SienaSienaItaly

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