Summary
The effects of some MAO inhibitors, N-acetylenic analogues of tryptamine, on rat liver microsomal cytochrome P-450 (cyt P-450) have been investigated. All the compounds tested interacted with cyt P-450 with Ks values ranging between 14 and 358 μM (clorgyline Ks = 10.5 μM). Compounds with a tertiary amine and those possessing a secondary amine group in the acetylenic side chain exhibited type I and type II difference spectra, respectively. Aniline hydroxylase activity was inhibited irreversibly and in a time-dependent fashion by all compounds tested with IC50 ranging between 7 x 10-5 and 7 x 10-3 M (clorgyline 10-4 M).
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© 1994 Springer-Verlag
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Costanzo, M., Valoti, M., Perez, V., Unzeta, M., Sgaragli, G.P. (1994). Interactions between substituted tryptamine analogues, MAO inhibitors and cytochrome P-450. In: Tipton, K.F., Youdim, M.B.H., Barwell, C.J., Callingham, B.A., Lyles, G.A. (eds) Amine Oxidases: Function and Dysfunction. Journal of Neural Transmission, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9324-2_38
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DOI: https://doi.org/10.1007/978-3-7091-9324-2_38
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