Acetylenic and allenic derivatives of 2-(5-methoxy-l-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B
A new series of thirty derivatives of 2-(5-methoxy-1-methylin-dolyl)alkylamines has been synthesized and the compounds assayed as inhibitors of MAO-A and MAO-B from bovine brain mitochondria. IC50 values for both isoenzymes were determined using tyramine as a common substrate. Structure-activity and selectivity relationships are dicussed. Key Words. Monoamine oxidane inhibitor design, acetylenic amine derivatives, allenic amine derivatives.
KeywordsMonoamine Oxidase Reference Compound Potassium Phosphate Residual Enzyme Activity Common Substrate
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