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Acetylenic and allenic derivatives of 2-(5-methoxy-l-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B

  • C. Fernández García
  • J. L. Marco
  • E. Fernández-Alvarez
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

A new series of thirty derivatives of 2-(5-methoxy-1-methylin-dolyl)alkylamines has been synthesized and the compounds assayed as inhibitors of MAO-A and MAO-B from bovine brain mitochondria. IC50 values for both isoenzymes were determined using tyramine as a common substrate. Structure-activity and selectivity relationships are dicussed. Key Words. Monoamine oxidane inhibitor design, acetylenic amine derivatives, allenic amine derivatives.

Keywords

Monoamine Oxidase Reference Compound Potassium Phosphate Residual Enzyme Activity Common Substrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Cruces MA, Elorriaga C, Fernández-Alvarez E, Nieto O (1990a) Acetylenic and allenic derivatives of 2-(5-methoxyindolyl)methylamine: synthesis and evaluation as selective inhibitors of monoamine oxidases A and B. Eur J Med Chem 25: 257–265.CrossRefGoogle Scholar
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • C. Fernández García
    • 1
  • J. L. Marco
    • 1
  • E. Fernández-Alvarez
    • 1
  1. 1.Instituto de Química Orgánica General (CSIC)Consejo Superior de Investigaciones CientíficasMadridSpain

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