Kinetic behaviour of some acetylenic indolalkylamine derivatives and their corresponding parent amines
Part of the
Journal of Neural Transmission
book series (NEURAL SUPPL, volume 41)
Different methoxy indolalkylamines based on a common structure, and differing in the side chain attached at the 2 position of the indole ring were studied as MAO A inhibitors. Some are acetylenic derivatives and consequently might behave as “suicide” MAO inhibitors (FA 42, FA 43, FA 45). The rest of compounds are the corresponding parent amines and they might behave as MAO substrates (FA 51, FA 52, FA 53, FA 54).
KeywordsMonoamine Oxidase Kinetic Behaviour Indole Ring Alkyl Side Chain Acetylenic Derivative
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