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Kinetic behaviour of some acetylenic indolalkylamine derivatives and their corresponding parent amines

  • D. Balsa
  • V. Pérez
  • E. Fernández-Alvarez
  • M. Unzeta
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

Different methoxy indolalkylamines based on a common structure, and differing in the side chain attached at the 2 position of the indole ring were studied as MAO A inhibitors. Some are acetylenic derivatives and consequently might behave as “suicide” MAO inhibitors (FA 42, FA 43, FA 45). The rest of compounds are the corresponding parent amines and they might behave as MAO substrates (FA 51, FA 52, FA 53, FA 54).

Keywords

Monoamine Oxidase Kinetic Behaviour Indole Ring Alkyl Side Chain Acetylenic Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Balsa D, Fernandez-Alvarez E, Tipton KF, Unzeta M (1991) Monoamine oxidase inhibitory potencies and selectivities of 2-[N-(2-propynyl) aminomethyl]-1-methyl indole derivatives. Biochem Soc Trans 19: 215–218.PubMedGoogle Scholar
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • D. Balsa
    • 1
  • V. Pérez
    • 1
  • E. Fernández-Alvarez
    • 2
  • M. Unzeta
    • 1
  1. 1.Departament de Bioquímica i Biologia Molecular, Facultat de MedicinaUniversitat Autönoma de BarcelonaBellaterra, BarcelonaSpain
  2. 2.Department de Química OrgánicaConsejo Superior de Investigaciones CientíficasMadridSpain

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