Advertisement

Monoamine oxidase-B in motor cortex and spinal cord in amyotrophic lateral sclerosis studied by quantitative autoradiography

  • S. S. Jossan
  • J. Ekblom
  • S.-M. Aquilonius
  • L. Oreland
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

The distribution of MAO-B was studied by using an in vitro quantitative autoradiographical method in the post-mortem spinal cord and motor cortex from control and ALS cases. 3H-L-deprenyl was used as a radiotracer. Sections stained with thionine were used to count glial cells.

Keywords

Spinal Cord Amyotrophic Lateral Sclerosis Corticospinal Tract Ventral Horn Amyotrophic Lateral Sclerosis Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan S-W, Seeburg PH, Shih JC (1988) c-DNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci USA 85: 4934–4938.PubMedCrossRefGoogle Scholar
  2. Bonduelle M (1975) Amyotrophic lateral sclerosis. In: Vinken PJ, Bruyn GW (eds) Handbook of neurology, vol 22. Elsevier, Amsterdam, pp 281–338.Google Scholar
  3. Fowler CJ, Oreland L, Marcusson J, Winblad B (1980) The effects of age on the activity and molecular properties of human brain monoamine oxidase. J Neural Transm 49: 1–20.PubMedCrossRefGoogle Scholar
  4. Johnston JP (1968) Some observations upon a new inhibitor of monoamine oxidase. Biochem Pharmacol 17: 1285–1297.PubMedCrossRefGoogle Scholar
  5. Jossan SS, Gillberg PG, d’Argy R, Aquilonius SM, Långstrom B, Halldin C, Oreland L (1991a) Quantitative localisation of human brain monoamine oxidase B by large section autoradiography using 3H-L-deprenyl. Brain Res 547: 69–76.PubMedCrossRefGoogle Scholar
  6. Jossan SS, Gillberg PG, Gottfries CG, Karlsson I, Oreland L (1991b) Monoamine oxidase B in brains from patients with Alzheimer’s disease: a biochemical and autoradiographical study. Neuroscience 45: 1–12.PubMedCrossRefGoogle Scholar
  7. Knoll J, Magyar K (1972) Some puzzling pharmacological effects of monoamine oxidase inhibition. Adv Biochem Psychopharmacol 5: 393–408.PubMedGoogle Scholar
  8. Kushner PD, Stephenson DT, Wright S (1991) Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain. Exp Neurol 50: 263–267.Google Scholar
  9. Stenström A, Hardy J, Oreland L (1987) Intra-and extra-dopamine-synaptosomal localisation of monoamine oxidase in striatal homogenates from four species. Biochem Pharmacol 18: 2931–2935.CrossRefGoogle Scholar
  10. Strolin-Benedetti M, Dostert P (1989) Monoamine oxidase, brain aging and degenerative diseases. Biochem Pharmacol 38: 555–561.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • S. S. Jossan
    • 1
  • J. Ekblom
    • 2
  • S.-M. Aquilonius
    • 2
  • L. Oreland
    • 1
  1. 1.Department of Medical PharmacologyUppsala UniversityUppsalaSweden
  2. 2.NeurologyUppsala UniversityUppsalaSweden

Personalised recommendations