Identification of human monoamine oxidase (MAO) A and B gene promoters
The promoter of human monoamine oxidase (MAO) A and B genes have been identified. The core promoter region of MAO A is comprised of two 90 bp repeats each of which contains two Sp1 elements and lacks a TATA box. The MAO B core promoter region contains two sets of overlapping Spl sites which flank a CACCC element all upstream of a TATA box. The different organization of the MAO A and B promoters may underlie their different cell and tissue specific expression.
KeywordsPromoter Activity Core Promoter Region Potential Transcription Factor Binding Site Decrease Promoter Activity Human Monoamine Oxidase
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