Lifespan of immunosuppressed NMRI-mice is increased by deprenyl

  • H.-J. Freisleben
  • F. Lehr
  • J. Fuchs
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)


Immunosuppressed NMRI-mice (nu/nu) were raised and kept under germ-reduced conditions and fed with a germ-reduced diet (14 animals = controls). For another 14 mice 4 mg of selegiline were admixed to 10 kg of the diet. The 50% survival rate of the latter group was 160% from birth or 220% from the beginning of the study. The survival rate in weeks finally reached 350%, and the aerea under the curve 250%. The last mouse in the control group died at the age of 5 months, 2.5 months after the study was started; the last mouse in the selegiline group died at the age of 14.5 months, 1 year after the beginning of the study.


Dopaminergic Neuron Premature Aging Increase Life Expectancy Immunosuppressed Mouse Extend Life Expectancy 
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • H.-J. Freisleben
    • 1
  • F. Lehr
    • 2
  • J. Fuchs
    • 2
  1. 1.Gustav-Embden-Zentrum der Biologischen ChemieKlinikum der Johann Wolfgang Goethe-UniversitätFrankfurt/MainFederal Republic of Germany
  2. 2.Zentrum der Dermatologie und VenerologieKlinikum der Johann Wolfgang Goethe-UniversitätFrankfurt am MainFederal Republic of Germany

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