Reboxetine prevents the tranylcypromine-induced increase in tyramine levels in rat heart
This study aimed to examine whether the increase in heart radioactivity levels after intravenous injection of 14C-tyramine to rats pretreated with the irreversible MAO inhibitor tranylcypromine could be antagonized by reboxetine, a potent and selective noradrenaline uptake blocker.
KeywordsMonoamine Oxidase Inhibitor Uptake Blocker Central Noradrenergic System Cheese Effect Tyramine Hydrochloride
Unable to display preview. Download preview PDF.
- Bieck PR, Antonin KH (1989) Tyramine potentiation during treatment with MAO inhibitors: brofaromine and moclobemide vs irreversible inhibitors. J Neural Transm [Suppl] 28: 21–31.Google Scholar
- Dollery CT, Brown MJ, Davies DS, Strolin Benedetti M (1984) Pressor amines and monoamine oxidase inhibitors. In: Tipton KF, Dostert P, Strolin Benedetti M (eds) Monoamine oxidase and disease. Prospects for therapy with reversible inhibitors. Academic Press, London, pp 429–441.Google Scholar
- Dostert P (1984) Myth and reality of the classical MAO inhibitors. Reasons for seeking a new generation. In: Tipton KF, Dostert P, Strolin Benedetti M (eds) Monoamine oxidase and disease. Prospects for therapy with reversible inhibitors. Academic Press, London, pp 9–24.Google Scholar
- Korn A, Da Prada M, Raffesberg W, Allen S, Gasic S (1988) Tyramine pressor effect in man: studies with moclobemide, a novel, reversible monoamine oxidase inhibitor. J Neural Transm [Suppl] 26: 57–71.Google Scholar
- Melloni P, Carniel G, Della Torre A, Bonsignori A, Buonamici M, Pozzi O, Ricciardi S, Rossi AC (1984) Potential antidepressant agents. a-Aryloxy-benzyl derivatives of ethanolamine and morpholine. Eur J Med Chem 19: 235–242.Google Scholar
- Riva M, Brunello N, Rovescalli AC, Galimberti R, Carfagna N, Carminati P, Pozzi O, Ricciardi S, Roncucci R, Rossi A, Racagni G (1989) Effect of reboxetine, a new antidepressant drug, on the central noradrenergic system: behavioural and biochemical studies. J Drug Dev 1: 243–253.Google Scholar
- Strolin Benedetti M, Dosiert P, Guffroy C, Tipton KF (1983) Partial or total protection from long-lasting monoamine oxidase inhibitors (MAOIs) by new short-acting MAOIs of type A MD 780515 and type B MD 780236. Mod Probi Pharmaco-psychiatry 19: 82–104.Google Scholar