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Clorgyline effect on pineal melatonin biosynthesis in roman high- and low-avoidance rats

  • P. J. Requintina
  • P. Driscoll
  • G. F. Oxenkrug
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

Pineal melatonin and related indoles levels were higher in Roman high- than in Roman low-avoidance rats, while 5-HIAA/5-HT ratio, as an index of MAO activity was higher in low- than in high-avoidance rats. Clorgyline stimulated pineal melatonin biosynthesis in both lines of rats. However, melatonin and N-acetylserotonin levels remained higher and 5-HIAA levels remained lower in the high avoidance rats treated with low dose (0.5 mg/kg) while treatment with 1.0 mg/kg of clorgyline eliminated the differences in melatonin production between high- and low-avoidance rats.

Keywords

Pineal Gland Melatonin Level Melatonin Production Pineal Melatonin Melatonin Biosynthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • P. J. Requintina
    • 1
  • P. Driscoll
    • 2
  • G. F. Oxenkrug
    • 1
  1. 1.Pineal Research Laboratory, Psychiatry Service, VAMC and Department of Psychiatry and Human BehaviorBrown University School of Medicine, T-20, VAMCProvidenceUSA
  2. 2.Behavior Biology LaboratoryETHZZürichSwitzerland

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