Clorgyline effect on pineal melatonin biosynthesis in roman high- and low-avoidance rats

  • P. J. Requintina
  • P. Driscoll
  • G. F. Oxenkrug
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)


Pineal melatonin and related indoles levels were higher in Roman high- than in Roman low-avoidance rats, while 5-HIAA/5-HT ratio, as an index of MAO activity was higher in low- than in high-avoidance rats. Clorgyline stimulated pineal melatonin biosynthesis in both lines of rats. However, melatonin and N-acetylserotonin levels remained higher and 5-HIAA levels remained lower in the high avoidance rats treated with low dose (0.5 mg/kg) while treatment with 1.0 mg/kg of clorgyline eliminated the differences in melatonin production between high- and low-avoidance rats.


Pineal Gland Melatonin Level Melatonin Production Pineal Melatonin Melatonin Biosynthesis 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • P. J. Requintina
    • 1
  • P. Driscoll
    • 2
  • G. F. Oxenkrug
    • 1
  1. 1.Pineal Research Laboratory, Psychiatry Service, VAMC and Department of Psychiatry and Human BehaviorBrown University School of Medicine, T-20, VAMCProvidenceUSA
  2. 2.Behavior Biology LaboratoryETHZZürichSwitzerland

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