Summary
Total suppression of righting reflex in frogs (Rana pipiens, 25–35 mg b.w.) was observed after combined administration of melatonin (12.5 mg/kg) and selective inhibitors of MAO-A: clorgyline (2.5 mg/kg) and moclobemide (50 mg/kg) but not MAO-B: selegiline (25 mg/kg) and Ro-19-6327 (50 mg/kg). None of these drugs alone affected the righting reflex. Clorgyline and selegiline selectively inhibited brain MAO-A and MAO-B activity (by more than 90%), resp. Frogs might represent a convenient model to study the selective MAO-A and B type inhibitors since they provide the opportunity to correlate behaviour and biochemical changes induced by MAO inhibitors.
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© 1994 Springer-Verlag
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Requintina, P.J., Oxenkrug, G.F., Yuwiler, A., Oxenkrug, A.G. (1994). Synergistic sedative effect of selective MAO-A, but not MAO-B, inhibitors and melatonin in frogs. In: Tipton, K.F., Youdim, M.B.H., Barwell, C.J., Callingham, B.A., Lyles, G.A. (eds) Amine Oxidases: Function and Dysfunction. Journal of Neural Transmission, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9324-2_19
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DOI: https://doi.org/10.1007/978-3-7091-9324-2_19
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82521-1
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