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Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A

  • J. P. M. Finberg
  • K. Pacak
  • D. S. Goldstein
  • I. J. Kopin
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

Chronic treatment of rats with clorgyline (1 mg/kg i.p. daily for 21 days) caused a highly significant increase in the concentration of noradrenaline in microdialysate from the frontal cortex of the awake animal. Acute (one injection, 2 mg/kg) or subacute (1 mg/kg daily for 3 days) treatment did not lead to a significant increase in microdialysate noradrenaline. Concentrations of deaminated metabolites (DPHG, MHPG, DOPAC) in the microdialysate decreased with time of treatment, reaching a minimum after 21 days.

Keywords

Chronic Inhibition Awake Animal Peripheral Sympathetic Nerve Renal Nerve Activity Locus Coeruleus Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • J. P. M. Finberg
    • 1
  • K. Pacak
    • 2
  • D. S. Goldstein
    • 2
  • I. J. Kopin
    • 2
  1. 1.Bruce Rappaport Faculty of MedicineTechnionHaifaIsrael
  2. 2.N. I. N. D. S., N. I. H.BethesdaUSA

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